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Exp Clin Endocrinol Diabetes 1989; 94(6): 387-390
DOI: 10.1055/s-0029-1210926
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Electrical Stimulation of the Limbic Structure on Adrenocortical Steroidogenesis in Hypophysectomized Rats

H. Saito, H. Kaba, T. Sato, A. Honmura, T. Kawakami1 , K. Seto, H. Yamamoto1 , M. Kawakami2
  • 1First Department of Physiology (Chairman: Prof. K. Seto), and Department of Orthopedic Surgery (Chairman: Prof. H. Yamamoto), Yokohama City University School of Medicine, Yokohama, Japan
  • 2Kochi Medical School, Nankoku, and Second Department of Physiology (Former Chairman: Prof. M. Kawakami) Yokohama City University School of Medicine, Yokohama, Japan
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

The effects of electrical stimulation of the medial amygdala (AMYG) and dorsal hippocampus (DHPC) on the rates of 14C transfer from 14C-l-acetate into adrenocortical steroids in adrenal slices of hypophysectomized rats were investigated. The 14C transfer rates into corticosterone were increased by stimulation of the AMYG and DHPC. The 14C transfer rates into cortisol were increased by the AMYG stimulation but were not altered by the DHPC stimulation. From these results, it might be suggested that these limbic structures were involved in the regulation of adrenocortical steroidogenesis without participation of the pituitary.

Key Words

Limbic Structure - Adrenocortical Steroids - Hypophysectomized rats

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