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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 115-120
DOI: 10.1055/s-0029-1210886
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

β-Adrenergic Modulation of the α2-Acute Phase Globulin Blood Level in Rats*)

M. Kahl, R. Schade
  • Institute of Pharmacology and Toxicology (Prof. Dr. sc. med. T. Ott), Department of Medicine (Charité), Humboldt University of Berlin, GDR
*) Dedicated to Professor Dr. G. Dörner on the occasion of his 60th birthday.
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

The acute phase response can be modulated by glucocorticoids and catecholamines as well.

We treated Wistar rats with either epinephrine or different selective or non-selective β-agonists in combination with β-antagonists. The α2-acute phase globulin (α2-APG) serum concentrations were examined by means of electroimmunodiffusion 24 hours after drug administration.

Isoprenaline, epinephrine and the β2-selective clenbuterol cause a dose-dependent increase in α2-APG serum concentration. The increase can be inhibited by propranolol as a non-selective β-recep-tor blocking agent, β-antagonist talinolol has no effect on the α2-APG serum level.

The dose-response curve of isoprenaline is shifted to the right and that of clenbuterol is additionally depressed after treatment with propranolol.

According to the α2-APG level the results indicate a β2-receptor mediated epinephrine action.

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