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Exp Clin Endocrinol Diabetes 1989; 93(1): 69-72
DOI: 10.1055/s-0029-1210838
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Glucagon into the Amygdala on Hepatic Acetate Metabolism in Rabbits

K. Seto, H. Saito, H. Kaba, M. Kondo, K. Kitaoka, K. Yoshida1 , A. Tamai1 , M. Kawakami2
  • 1First Department of Physiology (Chairman: Prof. Dr. K. Seto), and Department of Ophthalmology, (Chairman: Prof. Dr. A. Tamai)
  • 2Kochi Medical School, Nankoku, and Second Department of Physiology (Former Chairman: Prof. Dr. M. Kawakami)
  • Yokohama City University School of Medicine, Yokohama/Japan
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Glucagon was injected directly into the medial amygdala (AMYG) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 3 ng glucagon into the AMYG of intact rabbits increased the rates of 14C transfer from 14C-1-acetate into CO2, glucose, ketone bodies, cholesterol ester, free fatty acids and phospholipids but decreased those of 14C transfer into triglyceride. However, the glucagon injection into the AMYG of rabbits with lesions of stria terminals or into the parietal cortex of intact rabbits had no effects on the hepatic acetate metabolism. These observations support the hypothesis that the AMYG is a part of the glucagon-sensitive brain reguator system in the hepatic acetate metabolism.

Key Words

Glucagon - Amygdala - Acetate Metabolism

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