Vasopressin and Oxytocin Neurohypophysial Content under Conditions of Beta-Adrenergic Blockade in Euhydrated and Dehydrated Rats: Further Studies1)

Jolanta Janus; J. W. Guzek

doi:10.1055/s-0029-1210725

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1988; 91(1): 78-84
DOI: 10.1055/s-0029-1210725

Original

Vasopressin and Oxytocin Neurohypophysial Content under Conditions of Beta-Adrenergic Blockade in Euhydrated and Dehydrated Rats: Further Studies¹)

Jolanta Janus, J. W. Guzek

Department of Pathophysiology (Head: Prof. Dr. J. W. Guzek) University School of Medicine, Lödź/Poland

1) Conduced under contract No 06.03.3.5 with the Polish Academy of Sciences. A preliminary report, covering a part of the present findings, is accepted for publication in “Acta Physiologica Polonica”.

Abstract

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Summary

Rats euhydrated and dehydrated for two days were given intracerebroventricularly (i.c.v.) propranolol hydrochloride in a daily dose of 10 µg. In euhydrated rats the single dose of propranolol diminished significantly the vasopressin and oxytocin content in the neurohypophysis. On the contrary, in animals dehydrated for two days the depletion of the vasopressin and oxytocin neurohypophysial storage was distinctly less marked during i.c.v. treatment with propranolol.

Key words

Vasopressin - Oxytocin - Beta-Adrenergic Blockade

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