A Morphometric Study of the Effects of Melatonin on the Rat Adrenal Zona Glomerulosa

P. Rebuffat; G. Mazzocchi; A. Stachowiak; A. S. Belloni; A. Coi; G. G. Nussdorfer

doi:10.1055/s-0029-1210722

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Exp Clin Endocrinol Diabetes 1988; 91(1): 59-64
DOI: 10.1055/s-0029-1210722

Original

A Morphometric Study of the Effects of Melatonin on the Rat Adrenal Zona Glomerulosa

P. Rebuffat, G. Mazzocchi, A. Stachowiak, A. S. Belloni, A. Coi, G. G. Nussdorfer

Department of Anatomy, University of Padua/Italy

Weitere Informationen

Publikationsverlauf

1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The effects of a long-term administration of melatonin on the zona glomerulosa were investigated both in “normal” rats and in animals in which the hypothalamo-hypophyseal-adrenal axis and the renin-angiotensin system had been pharmacologically interrupted. Melatonin caused a notable hypertrophy of zona glomerulosa cells and a significant rise in the plasma concentration of aldosterone in both groups of rats. These findings indicate that melatonin exerts in vivo a strong direct stimulatory action on the growth and steroidogenic capacity of the rat zona glomerulosa.

Key words

Zona glomerulosa - Melatonin - Aldosterone - Morphometry - Rat