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Exp Clin Endocrinol Diabetes 1987; 90(6): 331-336
DOI: 10.1055/s-0029-1210709
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Effect of Oxotremorine on In-Vitro Secretion of Parathyroid Hormone1)

P. K. Wagner, U. Krause, M. Rothmund
  • Klinik für Allgemeinchirurgie (Head: Prof. Dr. M. Rothmund) der Philipps-Universität Marburg, FRG, and Endokrinologische Abteilung (Head: Prof. Dr. J. Beyer) der Johannes-Gutenberg-Universität Mainz/FRG
1) Herrn Prof. Dr. F. Kümmerle zum 70. Geburtstag.
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Publikationsverlauf

1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The effect of the muscarine-like acting parasympathomimetic drug oxotremorine and its antagonist atropine on PTH release was tested using single cell suspensions obtained from a) primary parathyroid adenomas, and b) secondary hyperplastic parathyroid tissue from patients undergoing chronic hemodialysis.

For both cell-types we found a dose-dependent suppression of PTH release with oxotremorine. The suppressive activity could be antagonized with atropine, suggesting that parasympathomimetic nerval impulses play a suppressive role in the regulation of PTH release. Muscarine-receptors appear to be responsible for this mechanism.

Key words

PTH-release - In vitro-Adenoma - Hyperplastic cells - Oxotremorine - Atropine