Download PDF
Exp Clin Endocrinol Diabetes 1987; 90(4): 120-122
DOI: 10.1055/s-0029-1210681
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Hyperglycemia on Serum T4 and T3 Levels in Rats

Tadasu Ikeda, Tatsuo Takeuchi, Yasuo Ito, Isao Murakami, Osamu Mokuda, Masato Tominaga, Hiroto Mashiba
  • The First Department of Internal Medicine, Tottori University School of Medicine, Yonago 683/Japan
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

In order to elucidate the effect of hyperglycemia on serum thyroid hormone levels, serum T4 and T3 concentrations were measured in rats with continuous intravenous glucose infusion. 30% glucose solution was infused into the left jugular vein at a rate of 1 ml/hr for 12 hr, and serum glucose level was maintained at 400 mg/dl. Serum T4 levels were slightly but not significantly decreased and serum T3 levels were significantly decreased by infusion of glucose for 12 hr. The ratio of serum T3 to T4 was not significantly changed in rats with glucose infusion.

These results suggest an inhibitory effect of hyperglycemia on thyroid hormone release.

Key words

Hyperglycemia - Intravenous glucose infusion - T4 - T3

      >