The Influence of Desmethylimipramine on the Hypothalamic and Neurohypophysial Vasopressin Content in Pinealectomized Male Rats1)

Mahlena Juszczak; J. W. Guzek

doi:10.1055/s-0029-1210669

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1987; 90(4): 26-36
DOI: 10.1055/s-0029-1210669

Original

The Influence of Desmethylimipramine on the Hypothalamic and Neurohypophysial Vasopressin Content in Pinealectomized Male Rats¹)

Mahlena Juszczak, J. W. Guzek

Department of Pathophysiology (Head: Prof. Dr. hab. med. J. W. Guzek), Institute of Pathology (Head: Prof. Dr. hab. med. Z. Torzecki), School of Medicine, Łodz/Poland

1) Conducted under contract No. 06.03.3.5. with the Polish Academy of Sciences.

Abstract

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Summary

The effect of desmethylimipramine (DMI) on the hypothalamic and neurohypophysial vasopressin content was investigated in normal and pinealectomized male rats. The vasopressor activity of the hypothalamus and neurohypophysis was bioassayed by the method of Dekanski (1952).

A single i.c.v. injection of DMI (20 μg; dissolved in 10 μl of normal saline) decreased vasopressin content in the neurohypophysis of non-operated and sham-operated animals. In pinealectomized rats the vasopressin content in the neurohypophysis diminished and was not modified by an i.c.v. DMI injection.

Repeated treatment with DMI (i.p. ; 10 mg/kg, twice a day over five days) resulted in a distinct increase of the hypothalamic and neurohypophysial vasopressin in both normal and pinealectomized rats.

Key words

Desipramine - Vasopressin - Pinealectomy

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