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Exp Clin Endocrinol Diabetes 1986; 88(4): 25-30
DOI: 10.1055/s-0029-1210570
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Reproductive Functions in the Adult Male Rats after Prolonged Intraventricular Administration of Corticotropin-Releasing Factor (CRF)

B. Miśkowiak, A. Janecki, A. Jakubowiak, A. Limanowski
  • Department of Histology and Embryology (Head: Ass. Prof. Dr. A. Lukaszyk), Poznań Academy of Medicine, Poznań/Poland
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

The effect of intraventricular injection of synthetic oCRF on reproductive functions in the male rats were studied and changes were compared with intact and control rats (daily intra -ventricular injections of 10 μl of 0.1% albumin solution in PBS). The long-term administration of oCRF into lateral ventricle of freely moving rats caused a significant increase in relative weights of adrenals, pituitary glands and a decrease in body weight. Plasma LH and testosterone levels were significantly depressed after 8 days of oCRF administration, while there were no alteration in studied parameters in the control rats. Control i.v.c. injections of 0.1% albumin solution in PBS were without effect on levels of any of the hormones or weights of testes, epidydimis, seminal vesicles and prostate. Obtained results indicate a central inhibitory action of oCRF on LH and subsequent testosterone release.

Key words

CRF - LH - Testosterone - Reproductive system

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