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Exp Clin Endocrinol Diabetes 1985; 86(5): 165-170
DOI: 10.1055/s-0029-1210482
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

On Steroid Noradrenergic System Interaction during the Hypothalamic Differentiation Period in the Female Rat

M. J. Vidal, E. Aguilar1
  • 1Departments of Pharmacology and Physiology, University of Córdoba/Spain
  • Faculty of Medicine, University of Córdoba/Spain
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

Neonatal administration of alpha-methyl-p-tyrosine, α-MPT, (l mg s. c. on days 4 and 5) or 6-hydroxydopamine, 6-OHDA, (100 or 600 µg s. c. on day 1) did not produce any change of the reproductive function in female rats. Both drugs were unable to prevent the anovulatory syndrome induced by the administration on day 4 of testosterone propionate, TP, (25 µg) or estradiol benzoate, EB, (10 µg), but blocked the precocious vaginal opening induced by EB neonatal administration.

These data suggested that the complete integrity of noradrenergic system appears to be not necessary for the differentiation of cyclic gonadotropin secretion in the female rat. This system seems to be involved in precocious vaginal opening induced by neonatal EB administration.

Key words

Hypothalamic differentiation - Noradrenergic system - Alpha-methyl-p-tyrosine - 6-Hydroxydopamine - Puberty

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