Download PDF
Exp Clin Endocrinol Diabetes 1985; 85(2): 253-256
DOI: 10.1055/s-0029-1210446
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Insulin into Ventromedial Hypothalamus on Acetate Metabolism in Liver Slices of Rabbit

K. Seto, H. Saito, H. Kaba, J. Tanaka, A. Iguchi1 , N. Sakamoto1 , M. Kawakami†2
  • 1First Department of Physiology (Chairman: Prof. Dr. K. Seto), Kochi Medical School, Nankoku, Third Department of Internal Medicine (Chairman: Prof. Dr. N. Sakamoto), Yokohama City University School of Medicine, Yokohama/Japan
  • 2Nagoya University School of Medicine, Nagoya, and Second Department of Physiology, Yokohama City University School of Medicine, Yokohama/Japan
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Insulin was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 50µU insulin into the VMH of intact rabbits decreased the rates of 14C transfer from 14C-1-acetate into glucose and cholesterol ester in liver slices. But after insulin injection into the parietal cortex of intact rabbits and into the VMH of rabbits with VMH lesions, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of an insulin-sensitive brain regulator system in the hepatic acetate metabolism.

Key words

Insulin - acetate metabolism - ventromedial hypothalamus - rabbit

      >