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Exp Clin Endocrinol Diabetes 1984; 84(5): 218-222
DOI: 10.1055/s-0029-1210390
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Species Differences in Levonorgestrel Binding to Serum Proteins of Monkey, Rabbit and Rat Blood

A. K. Srivastava, Gyan Chandra, S. K. Roy
  • Division of Endocrinology, Central Drug Research Institute, Lucknow/India
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Publication History

1983

Publication Date:
17 July 2009 (online)

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Summary

Levonorgestrel binding to serum proteins of monkey, rabbit and rat was studied. It showed high affinity binding to monkey and rabbit serum proteins but not to rat serum. Characterization by polyacrylamide gel electrophoresis revealed that the binding of levonorgestrel occurs to sex hormone binding globulin (SHBG) and albumin, but in rat it is confined to albumin only. These results suggest species differences in levonorgestrel binding to serum proteins and extrapolation of data from one animal model to another may not be directly feasible.

Key words

Levonorgestrel - serum protein binding - monkey - rabbit - rat