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Exp Clin Endocrinol Diabetes 1984; 84(4): 126-128
DOI: 10.1055/s-0029-1210376
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Induction of Puberty in a Patient with Hypogonadotropic Hypogonadism by Pulsatile, Subcutaneous Infusions of LH-RH

H. Vierhapper
  • Ist Medical Clinic of the University (Head: Prof. Dr. Dr. h.c. E. Deutsch), Division of Clinical Endocrinology and Diabetes Mellitus (Head: Prof. Dr. W. Waldhäusl), Vienna/Austria
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Publication History

1983

Publication Date:
17 July 2009 (online)

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Summary

Following treatment with nocturnal, pulsatile, s.c. infusions of LH-RH (50 μg/ night) for nine nights a twenty-year-old patient with hypogonadotropic hypogonadism presented a markedly enhanced, biphasic secretion of LH during an LH-RH infusion test (200 μg LH-RH i.V., t = 4 hours) indicating a hypothalamic defect and a deficiency in endogenous LH-RH production. Puberty was subsequently initiated in this patient within eight weeks of therapy with s.c. pulsatile LH-RH. These results confirm that intermittent application of LH-RH induces pituitary sensitization resulting in an enhanced response to exogenous LH-RH. This will help to select patients for prolonged therapy with intermittent s.c. LH-RH for the initiation of puberty.

Key words

LH-RH - pulsatile therapy - hypogonadotropic hypogonadism - puberty

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