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Int J Sports Med 2009; 30(8): 624-627
DOI: 10.1055/s-0029-1202825
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

The Angiotensin Converting Enzyme Gene I/D Polymorphism in Polish Rowers

P. Cieszczyk 1 , K. Krupecki 1 , A. Maciejewska 2 , M. Sawczuk 2
  • 1Institute of Physical Culture, University of Szczecin, Szczecin, Poland
  • 2Department of Genetics, University of Szczecin, Szczecin, Poland
Further Information

Publication History

accepted after revision January 16, 2009

Publication Date:
19 May 2009 (online)

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Abstract

Angiotensin converting enzyme gene (ACE) is the most frequent investigated gene in the context of genetic conditioning of sports-predispositions. Product of this gene is a key-element in the renin-angiotensin system responsible for the regulation of blood pressure. In this study DNA polymorphism in the ACE gene was studied in Polish rowers in order to examine the hypothesis that ACE genotype is associated with athletes performance. Fifty-five male Polish rowers including Olympic and World champions were recruited for this study. Control samples were prepared from 115 unrelated volunteers. PCR amplification of the insertion (I) or deletion (D) fragment of ACE gene was performed. Genotype distribution and allele frequencies were determined by genotype and gene counting. Significance was assessed by χ2 analysis. ACE genotype distributions amongst subjects and controls were in Hardy-Weinberg equilibrium. Compared with controls, the frequency of I allele differ significantly from that found in rower's group: 56.3% vs. 44.3%, (P=0.038) and ACE genotype frequency amongst the whole athletes group (30.9% II, 50.9% ID, 18.2% DD) was also different from expected values (control group 19.1% II, 50.4% ID, 30.4% DD; P=0.039). This data confirm a positive association of the I allele of ACE gene with endurance performance.

Key words

angiotensin converting enzyme - insertion/delition allele - population genetic - endurance performance

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Correspondence

Dr. A. MaciejewskaPhD 

Department of Genetics

University of Szczecin

Al. Piastow 40B

71-045 Szczecin

Poland

Phone: +48/914/44 27 83

Fax: +48/914/44 27 80

Email: maciejewska.us@wp.pl

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