Why Treat the Male in the Era of Assisted Reproduction?

ABSTRACT

The concept of unilateral care of the female partner has gained momentum in the reproductive health community, especially with the advent of in vitro fertilization and intracytoplasmic sperm injection. Herein, the authors examine the existing evidence in support of evaluating and treating the male patient as part of the routine evaluation of the infertile couple. This evidence includes assessments of efficacy, cost-effectiveness, and safety, and-- when considered broadly--argues strongly against unilateral care.

KEYWORDS

In vitro fertilization - intracytoplasmic sperm injection - assisted reproductive techniques - male infertility

REFERENCES

• 1 Nicopoullos J D, Gilling-Smith C, Ramsay J W. Male-factor infertility: do we really need urologists? A gynaecological view.  BJU Int. 2004;  93 1188-1190
• 2 Tournaye H. Evidence-based management of male subfertility.  Curr Opin Obstet Gynecol. 2006;  18 253-259
• 3 Zegers-Hochschild F, Nygren K G, Adamson G D et al.. The ICMART glossary on ART terminology.  Hum Reprod. 2006;  21 1968-1970
• 4 Steptoe P C, Edwards R G. Birth after the reimplantation of a human embryo.  Lancet. 1978;  2 366
• 5 Kolettis P N, Sabanegh E S. Significant medical pathology discovered during a male infertility evaluation.  J Urol. 2001;  166 178-180
• 6 Honig S C, Lipshultz L I, Jarow J. Significant medical pathology uncovered by a comprehensive male infertility evaluation.  Fertil Steril. 1994;  62 1028-1034
• 7 Ferguson-Smith M A, Lennox B, Mack W S, Stewart J S. Klinefelter's syndrome; frequency and testicular morphology in relation to nuclear sex.  Lancet. 1957;  273 167-169
• 8 Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.  Hum Genet. 1976;  34 119-124
• 9 Anguiano A, Oates R D, Amos J A et al.. Congenital bilateral absence of the vas deferens. A primarily genital form of cystic fibrosis.  JAMA. 1992;  267 1794-1797
• 10 Collins F S. Cystic fibrosis: molecular biology and therapeutic implications.  Science. 1992;  256 774-779
• 11 Rosenstein B J, Cutting G R. The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel.  J Pediatr. 1998;  132 589-595
• 12 Ratjen F, Doring G. Cystic fibrosis.  Lancet. 2003;  361 681-689
• 13 Wright V C, Schieve L A, Reynolds M A et al.. Assisted reproductive technology surveillance–United States, 2002.  MMWR Surveill Summ. 2005;  54 1-24
• 14 Thurin A, Hausken J, Hillensjo T et al.. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization.  N Engl J Med. 2004;  351 2392-2402
• 15 Poikkeus P, Gissler M, Unkila-Kallio L, Hyden-Granskog C, Tiitinen A. Obstetric and neonatal outcome after single embryo transfer.  Hum Reprod. 2007;  22 1073-1079
• 16 Neumann P J, Gharib S D, Weinstein M C. The cost of a successful delivery with in vitro fertilization.  N Engl J Med. 1994;  331 239-243
• 17 Deck A J, Berger R E. Should vasectomy reversal be performed in men with older female partners?.  J Urol. 2000;  163 105-106
• 18 Hollingsworth B, Harris A, Mortimer D. The cost effectiveness of intracyctoplasmic sperm injection (ICSI).  J Assist Reprod Genet. 2007;  24 571-577
• 19 Gorelick J I, Goldstein M. Loss of fertility in men with varicocele.  Fertil Steril. 1993;  59 613-616
• 20 Jarow J P, Coburn M, Sigman M. Incidence of varicoceles in men with primary and secondary infertility.  Urology. 1996;  47 73-76
• 21 Schlegel P N. Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis.  Urology. 1997;  49 83-90
• 22 Kolettis P N, Thomas Jr A J. Vasoepididymostomy for vasectomy reversal: a critical assessment in the era of intracytoplasmic sperm injection.  J Urol. 1997;  158 467-470
• 23 Pavlovich C P, Schlegel P N. Fertility options after vasectomy: a cost-effectiveness analysis.  Fertil Steril. 1997;  67 133-141
• 24 Garceau L, Henderson J, Davis L J et al.. Economic implications of assisted reproductive techniques: a systematic review.  Hum Reprod. 2002;  17 3090-3109
• 25 Gorelick J I, Goldstein M. Loss of fertility in men with varicocele.  Fertil Steril. 1993;  59 613-616
• 26 Nicopoullos J D, Gilling-Smith C, Ramsay J W. Male-factor infertility: do we really need urologists? A gynaecological view.  BJU Int. 2004;  93 1188-1190
• 27 Schlegel P N, Li P S. Microdissection TESE: sperm retrieval in non-obstructive azoospermia.  Hum Reprod Update. 1998;  4 439
• 28 Tournaye H. Evidence-based management of male subfertility.  Curr Opin Obstet Gynecol. 2006;  18 253-259
• 29 Maher E R. Imprinting and assisted reproductive technology.  Hum Mol Genet. 2005;  14 133-138
• 30 Maher E R, Brueton L A, Bowdin S C et al.. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART).  J Med Genet. 2003;  40 62-64
• 31 Ludwig M, Katalinic A, Gross S et al.. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples.  J Med Genet. 2005;  42 289-291
• 32 Maduro M R, Casella R, Kim E et al.. Microsatellite instability and defects in mismatch repair proteins: a new aetiology for Sertoli cell-only syndrome.  Mol Hum Reprod. 2003;  9 61-68
• 33 Practice Committee of the American Society for Reproductive Medicine . Genetic considerations related to intracytoplasmic sperm injection (ICSI).  Fertil Steril. 2006;  86(5, Suppl) S103-S105
• 34 ACOG Committee on Practice Bulletins-Gynecology . Clinical management guidelines for obstetrician-gynecologists number 34, February 2002. Management of infertility caused by ovulatory dysfunction. American College of Obstetricians and Gynecologists.  Obstet Gynecol. 2002;  99 347-358