Abstract
Two new ent-kaurane diterpenoids, 16,17-exo-epoxide-oridonin (1) and 11,15-O,O-diacetyl-rabdoternins D (2), together with thirteen known ones, were isolated from the aerial parts of Rabdosia rubescens. Their structures were established on the basis of high-field 1D and 2D NMR methods
supported by HRMS. All diterpenoids were tested for cytotoxicity against human Hep
G2, COLO 205, MCF-7, and HL-60 cancer cells. The compounds oridonin (3), 14-O-acetyl-oridonin (4), 1,14-O,O-diacetyl-oridonin (5), rosthorin (6), effusanin E (7), and ponicidin (8), as well as six α-methylene γ-ketone bearing diterpenoids, were modestly active in these assays.
Key words
Rabdosia rubescens
- Labiatae -
ent‐kaurane - cytotoxicity - antitumor
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Chi-Tang Ho
Department of Food Science
Rutgers University
65 Dudley Road
New Brunswick, NJ 08901
USA
Telefon: + 1 73 29 32 96 11 ext. 235
Fax: + 1 73 29 32 67 76
eMail: ho@aesop.rutgers.edu
