HPLC‐SPE‐NMR Identification of a Novel Metabolite Containing the Benzo[c]oxepin Skeleton from the Endophytic Fungus Pestalotiopsis virgatula Culture

Abstract

HPLC‐SPE‐NMR analysis of a crude extract of fermentation broth of cultured Pestalotiopsis virgatula isolate TC-320 from Terminalia chebula Retz. (Combretaceae) disclosed the presence of a simple but unprecedented low-molecular-weight metabolite, 9-hydroxybenzo[c]oxepin-3[1H]-one, subsequently isolated by a targeted purification procedure.

Key words

endophytes - Pestalotiopsis virgatula - Amphisphaeriaceae - HPLC‐SPE‐NMR - NMR hyphenation

References

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