Planta Med 2010; 76(2): 107-112
DOI: 10.1055/s-0029-1185950
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antinociceptive Activity of the Essential Oil of Zingiber zerumbet

Mohd Roslan Sulaiman1 , 3 , Tengku Azam Shah Tengku Mohamad1 , Wan Mastura Shaik Mossadeq1 , Saidi Moin1 , Mazina Yusof3 , Ahmad Fauzi Mokhtar3 , Zainul Amiruddin Zakaria2 , Daud Ahmad Israf1 , 3 , Nordin Lajis3 , 4
  • 1Department of Biomedical Science, University Putra Malaysia, Serdang, Malaysia
  • 2Department of Pharmacology, University Teknologi Mara, Shah Alam, Selangor, Malaysia
  • 3Institute of Bioscience, University Putra Malaysia, Serdang, Malaysia
  • 4Department of Chemistry, University Putra Malaysia, Serdang, Malaysia
Further Information

Publication History

received April 28, 2009 revised June 21, 2009

accepted June 25, 2009

Publication Date:
27 July 2009 (online)


In the present study, the rhizome essential oil from Zingiber zerumbet (Zingiberaceae) was evaluated for antinociceptive activity using chemical and thermal models of nociception, namely, the acetic acid-induced abdominal writhing test, the hot-plate test and the formalin-induced paw licking test. It was demonstrated that intraperitoneal administration of the essential oil of Z. zerumbet (EOZZ) at the doses of 30, 100 and 300 mg/kg produced significant dose-dependent inhibition of acetic acid-induced abdominal writhing, comparable to that of obtained with acetylsalicylic acid (100 mg/kg). At the same doses, the EOZZ produced significant dose-dependent increases in the latency time in the hot-plate test with respect to controls, and in the formalin-induced paw licking test, the EOZZ also significantly reduced the painful stimulus in both neurogenic and inflammatory phase of the test. In addition, the antinociceptive effect of the EOZZ in the formalin-induced paw licking test as well as hot-plate test was reversed by the nonselective opioid receptor antagonist, naloxone suggesting that the opioid system was involved in its analgesic mechanism of action. On the basis of these data, we concluded that the EOZZ possessed both central and peripheral antinociceptive activities which justifying its popular folkloric use to relieve some pain conditions.


Prof. Dr. Mohd Roslan Sulaiman

Department of Biomedical Science
Faculty of Medicine and Health Sciences
University Putra Malaysia

43400 Serdang



Phone: + 60 3 89 47 26 03

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