Subscribe to RSS
DOI: 10.1055/s-0029-1185510
© Georg Thieme Verlag KG Stuttgart · New York
Antifungal and Anthelmintic Activities of Cleistopholis patens (Annonaceae)
Publication History
received December 17, 2008
revised February 11, 2009
accepted February 16, 2009
Publication Date:
26 March 2009 (online)
Abstract
Basic CH2Cl2 extract of the trunk bark of Cleistopholis patens (Annonaceae) exhibited antifungal activities against Candida albicans, C. parapsilosis, and C. glabrata using an agar well-diffusion assay method. Bioassay-guided fractionation of the extract led to the isolation of 8-hydroxysampangine. The methanolic extract displayed anthelmintic activity against Rhabditis pseudoelongata. Purification of the neutral CH2Cl2 extract yielded bornyl-p-trans-coumarate and bornyl-p-cis-coumarate.
Key words
Cleistopholis patens (Annonaceae) - 8‐hydroxysampangine - antifungal - Candida - anthelmintic - Rhabditis
- Supporting Information for this article is available online at
- Supporting Information .
References
- 1 Le Thomas A. Flore du Gabon, no. 16. Annonacées. Paris; Muséum National d'Histoire Naturelle 1969: 91-94
- 2 Abd-El Atti S, Ammar H A, Phoebe Jr C H, Schiff Jr P L, Slatkin D J. Alkaloids of Guatteria melosma and Cleistopholis patens. J Nat Prod. 1982; 45 476-480
- 3 Waterman P G, Muhammad I. Sesquiterpenes and alkaloids from Cleistopholis patens. Phytochemistry. 1985; 24 523-527
- 4 Liu S, Oguntimein B, Hufford C D, Clark A M. 3-Methoxysampangine, a novel antifungal copyrine alkaloid from Cleistopholis patens. Antimicrob Agent Chemother. 1990; 34 529-533
- 5 Akendengué B, Ngou Milama E, Laurens A, Hocquemiller R. 8-Hydroxysampangine, a new alkaloid isolated from Cleistopholis patens (Annonaceae). Nat Prod Lett. 1999; 13 147-150
- 6 Hu J F, Garo E, Hough G W, Goering M G, O'Neil-Johnson M, Eldridge G R. Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. J Nat Prod. 2006; 69 585-590
-
7 Espinel-Ingroff A V, Pfaller M A.
Susceptibility test methods: yeasts and filamentous fungi. Murray PR Manual of clinical microbiology, 9th edition, Vol. 2. Washington; ASM Press 2007: 1972-1986 - 8 Hufford C D, Liu S, Clark A M. Anticandidal activity of eupolauridine and onychine, alkaloids from Cleistopholis patens. J Nat Prod. 1987; 50 961-964
- 9 Orabi K Y. Characterization of the major metabolite of sampangine in rats. J Nat Prod. 2000; 63 685-687
- 10 Han G Q, Huang Q L. Two new cinnamic acid derivates from Magnolia biondii Pamp. Chin Chem Lett. 1993; 4 33-34
- 11 Mongelli E, Martianez J, Anaya J, Grande C, Grande M, Torres P, Pomilio A B. Bolax gummifera: toxicity against Artemia sp. of bornyl and iso-bornyl esters. Mol Med Chem. 2003; 1 26-29
- 12 Montagnac A, Provost J P, Litaudon M, Pais M. Antimitotic and cytotoxic constituents of Myodocarpus gracilis. Planta Med. 1997; 63 365-366
- 13 Maldonado E, Ramirez Apan M T, Perez-Castorena A L. Anti-inflammatory activity of phenyl propanoids from Coreopsis mutica var. mutica. Planta Med. 1998; 68 660-661
- 14 Hernandez V M, Miranda R. Presence of bornyl p-coumarate in the roots of Eupatorium deltoideum. J Nat Prod. 1986; 49 1173-1174
- 15 Caujolle R, Payard M, Loiseau P R, Amarouch H, Linas M D, Séguéla J P, Bories C, Loiseau P M, Gayral P. Synthesis, antiparasitic and antifungic activity of thioureines with amino acid chain. Eur J Med Chem. 1991; 26 723-727
Prof. Blandine Akendengué
Département de Pharmacologie
Faculté de Médecine
Université des Sciences de la Santé
BP 7464
Libreville
Gabon
Phone: + 24 1 05 81 24 14
Email: akenblan@yahoo.fr
- www.thieme-connect.de/ejournals/toc/plantamedica