Planta Med 2009; 75(10): 1143-1145
DOI: 10.1055/s-0029-1185510
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antifungal and Anthelmintic Activities of Cleistopholis patens (Annonaceae)

Blandine Akendengué1 , Pierre Champy2 , Joseph Nzamba3 , François Roblot2 , Philippe M. Loiseau2 , Christian Bories2
  • 1Département de Pharmacologie, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon
  • 2Laboratoire de Chimie des Substances Naturelles et Chimiothérapie Antiparasitaire, 8076 CNRS BioCIS, Faculté de Pharmacie, Châtenay-Malabry, France
  • 3Département de Parasitologie, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon
Further Information

Publication History

received December 17, 2008 revised February 11, 2009

accepted February 16, 2009

Publication Date:
26 March 2009 (online)

Abstract

Basic CH2Cl2 extract of the trunk bark of Cleistopholis patens (Annonaceae) exhibited antifungal activities against Candida albicans, C. parapsilosis, and C. glabrata using an agar well-diffusion assay method. Bioassay-guided fractionation of the extract led to the isolation of 8-hydroxysampangine. The methanolic extract displayed anthelmintic activity against Rhabditis pseudoelongata. Purification of the neutral CH2Cl2 extract yielded bornyl-p-trans-coumarate and bornyl-p-cis-coumarate.

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Prof. Blandine Akendengué

Département de Pharmacologie
Faculté de Médecine
Université des Sciences de la Santé

BP 7464

Libreville

Gabon

Phone: + 24 1 05 81 24 14

Email: akenblan@yahoo.fr