Planta Med 2009; 75(10): 1118-1123
DOI: 10.1055/s-0029-1185507
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antioxidant and Hepatoprotective Activities of Thai Mango Seed Kernel Extract

Saruth Nithitanakool1 , Pimolpan Pithayanukul1 , Rapepol Bavovada2
  • 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
  • 2Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
Further Information

Publication History

received Sept. 1, 2008 revised February 13, 2009

accepted February 16, 2009

Publication Date:
26 March 2009 (online)

Abstract

Three polyphenolic principles, 1,2,3,4,6-penta-O-galloyl-β‐D-glucopyranose (PGG), methyl gallate (MG), and gallic acid (GA), were isolated from the ethanolic extract of seed kernels of Thai mango (MSKE) (Mangifera indica L. cv. “Fahlun”) and quantified using a TLC scanning densitometric method. The MSKE and its isolates were investigated by studying their antioxidant capacities using four different methods, by determining their in vitro anti-inflammatory activities, and by evaluating their hepatoprotective potential against liver injury in rats induced by carbon tetrachloride (CCl4). The hepatoprotective effect of MSKE is clearly supported by its polyphenolic nature of the main principle, PGG, which exhibited potent antioxidant and anti-inflammatory activities.

References

Associate Prof. Dr. Pimolpan Pithayanukul

Department of Pharmacy
Faculty of Pharmacy
Mahidol University

447 Sri-Ayudthaya road, Payatai

Bangkok 10400

Thailand

Phone: + 66 26 44 86 94

Email: [email protected]