Planta Med 2009; 75(10): 1157-1161
DOI: 10.1055/s-0029-1185505
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Carboline Alkaloids from Trigonostemon lii

Xu-Jia Hu1 , 2 , 3 , Ying-Tong Di1 , Yue-Hu Wang1 , Ling-Yi Kong3 , Suo Gao1 , Chun-Shun Li1 , Hai-Yang Liu1 , Hongping He1 , Jian Ding4 , Hua Xie4 , Xiaojiang Hao1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Yunnan Institute of Food and Drug Control, Kunming, P. R. China
  • 3Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
  • 4Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai, P. R. China
Further Information

Publication History

received April 30, 2008 revised January 8, 2009

accepted February 17, 2009

Publication Date:
26 March 2009 (online)

Abstract

Three types with six new carboline alkaloids, trigonostemonines A–F (16), were isolated from the roots and stems of Trigonostemon lii. Their structures were elucidated by spectroscopic analyses. It is the first time that β-carboline alkaloids have been reported in Trigonostemon species. Trigonostemonine F (6) exhibited moderate cytotoxic activity against HL-60 with an IC50 value of 16 µM.

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Prof. Dr. Xiao-Jiang Hao

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

Kunming 650204

People's Republic of China

Phone: + 86 87 15 22 32 63

Fax: + 86 87 15 21 96 84

Email: haoxj@mail.kib.ac.cn