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DOI: 10.1055/s-0029-1185483
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic Phenanthroindolizidine Alkaloids from the Roots of Ficus septica
Publication History
received April 17, 2008
revised February 3, 2009
accepted February 17, 2009
Publication Date:
18 March 2009 (online)
Abstract
Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids, including ten new ficuseptines E–N (1–10) and ten known compounds. The cytotoxic effects of some of the isolates were tested on gastric adenocarcinoma (NUGC) and nasopharyngeal carcinoma (HONE-1) cell lines and the results demonstrated that, with the exception of dehydrotylophorine, all the tested compounds displayed pronounced cytotoxic activity with significant cell growth inhibitory effects. In addition, 13aR-antofine was found to be highly effective with ED50 values of < 0.1 µg/mL against L-1210, P-388, A-549 and HCT-8 cell lines in another assay.
Key words
Ficus septica - Moraceae - phenanthroindolizidines - cytotoxicity - ficuseptine
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