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DOI: 10.1055/s-0028-1109297
© Georg Thieme Verlag KG Stuttgart · New York
Maligne Hyperthermie und deren Differenzialdiagnosen
Malignant Hyperthermia and its Differential DiagnosisPublication History
Publication Date:
03 April 2009 (online)
Zusammenfassung
Hyperthermie führt zu einer Beeinflussung verschiedener Körper-Regelgrößen, wobei insbesondere Interaktionen mit dem kardiovaskulären bzw. dem zentralen Nervensystem zu lebensbedrohlichen Folgen führen können. Der vorliegende Beitrag beschreibt die Symptome, die Pathogenese und die Therapieansätze der häufigsten 3 Hyperthermie-Syndrome (maligne Hyperthermie, Serotonin-Syndrom und malignes neuroleptisches Syndrom). Dem Leser die differenzialdiagnostische Abgrenzung dieser 3 Entitäten zu erleichtern, ist das Ziel dieser Übersicht. Weiterhin wird die mögliche Assoziation zwischen Myopathien und Hyperthermie-Syndromen diskutiert.
Abstract
Hyperthermia affects almost all endogenous regulatory systems, where especially cardiovascular and central nervous system interactions can result in life threatening complications. This review illustrates signs and symptoms, pathophysiology and therapeutic options of the three most common hyperthermic syndromes in neurology: malignant hyperthermia, serotonine-syndrom and malignant neuroleptic syndrome. The aim of this contribution is to enable the reader to make the differential diagnosis of these three disease entities. Furthermore the association of other specific myopathies and hyperthermia syndromes is discussed.
Schlüsselwörter
Hyperthermie-Syndrome - maligne Hyperthermie - Serotonin-Syndrom - malignes neuroleptisches Syndrom - Ryanodin-Rezeptor
Key words
hyperthermia-syndromes - malignant hyperthermia - serotonine-syndrome - malignant neuroleptic syndrome - Ryanodine receptor
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Dr. med. Katrin Hüttemann
Kopfklinik, Neurologische Klinik Universitätsklinikum Erlangen
Schwabachanlage 6
91054 Erlangen
Email: Katrin.Huettemann@uk-erlangen.de