Zusammenfassung
Aus tierexperimentellen und epidemiologischen Studien gibt es Hinweise darauf, dass
körperliche Aktivität neuroprotektiv ist und den kognitiven Abbau im Rahmen eines
chronisch neurodegenerativen Prozesses wie der Demenz vom Alzheimer-Typ verhindern
kann. Im Gegensatz zur Hypertonus- und Diabetesprävention und der Beeinflussung des
metabolischen Syndroms unter Antipsychotika gibt es bei der Demenz aber leider bislang
keine qualitativ hochwertigen nicht medikamentösen Interventionsstudien. Solange im
Frühstadium der Demenz keine anderen Therapien verfügbar sind, würde der Nachweis
eines potenziell positiven Effekts von körperlicher Aktivität auf die Entwicklung
einer Demenz in einer Interventionsstudie einen bedeutenden Fortschritt nicht nur
für die Demenzprävention, sondern auch für die öffentliche Gesundheit darstellen.
Abstract
There is accumulating evidence from animal and epidemiologic studies that physical
exercise is neuroprotective in healthy animals and humans and can prevent cognitive
decline in chronic neurodegenerative processes like Alzheimer’s dementia. However,
data from well-designed interventional, randomized non-pharmacologic trials is lacking
in contrast to other areas of medicine like prevention of hypertension, diabetes or
the antipsychotic-associated metabolic syndrome. The demonstration of a potential
positive effect of physical exercise on preventing dementia using a controlled study
design would represent a significant progress in the prevention of dementia and public
health, especially as long as other treatments for dementia prevention are lacking.
Schlüsselwörter
Gesundheitsförderung - Demenz - Gesundheitsökonomie
Key words
health promotion - dementia - health economics
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Prof. Dr. Markus Weih
MME (Bern), Psychiatrische und Psychotherapeutische Klinik, Universitätsklinikum Erlangen
Schwabachanlage 6
91054 Erlangen
Email: markus.weih@uk-erlangen.de