S3-Leitlinie „Helicobacter pylori und gastroduodenale Ulkuskrankheit” der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS)

Zusammenfassung

Die Leitlinie akualisiert eine frühere Konsensusempfehlung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) aus dem Jahr 1996. Sie wurde interdisziplinär in Zusammenarbeit mit Vertretern der Deutschen Gesellschaft für Hygiene und Mikrobiologie, der Gesellschaft für Pädiatrische Gastroenterologie und Ernährung e. V. und der Deutschen Gesellschaft für Rheumatologie erstellt. Die Leitlinie basiert auf den Empfehlungen der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) für eine systematische evidenzbasierte Konsensus-Leitlinie der Entwicklungsstufe S 3 und hat auch die Bewertungskriterien der GRADE (Grading of Recommendations Assessment, Development and Evaluation) implemetiert. Die Anwendbarkeit der Studienergebnisse und spezifische Gegebenheiten in Deutschland im Hinblick auf Epidemiologie, Resistenzlage, Diagnostik und Therapie wurden berücksichtigt.

Abstract

This guideline updates a prior concensus recommendation of the German Society for Digestive and Metabolic Diseases (DGVS) from 1996. It was developed by an interdisciplinary cooperation with representatives of the German Society for Microbiology, the Society for Pediatric Gastroenterology and Nutrition (GPGE) and the German Society for Rheumatology. The guideline is methodologically based on recommendations of the Association of the Scientific Medical Societies in Germany (AWMF) for providing a systematic evidence-based consensus guideline of S 3 level and has also implemented grading criteria according to GRADE (Grading of Recommendations Assessment, Development and Evaluation). Clinical applicability of study results as well as specifics for Germany in terms of epidemiology, antibiotic resistance status, diagnostics and therapy were taken into account.

Schlüsselwörter

Helicobacter pylori - gastroduodenale Ulzera - Ulkuskrankheit

Key words

Helicobacter pylori - gastroduodenal ulcer - ulcer disease

Literatur

• 1 Preiß J C, Timmer A, Zeitz M. et al . Neue Konzepte der Leitlinienmethodik.  Z Gastroenterol. 2007;  45 1075-1081
• 2 Graham D Y, Adam E, Reddy G T. et al . Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries.  Dig Dis Sci. 1991;  36 (8) 1084-1088
• 3 Megraud F, Brassens-Rabbe M P, Denis F. et al . Seroepidemiology of Campylobacter pylori infection in various populations.  J Clin Microbiol. 1989;  27 (8) 1870-1873
• 4 Redlinger T, O’Rourke K, Goodman K J. Age distribution of Helicobacter pylori seroprevalence among young children in a United States/Mexico border community: evidence for transitory infection.  Am J Epidemiol. 1999;  150 (3) 225-230
• 5 Taylor D N, Blaser M J. The epidemiology of Helicobacter pylori infection.  Epidemiol Rev. 1991;  13 42-59
• 6 Malaty H M, Graham D Y. Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection.  Gut. 1994;  35 (6) 742-745
• 7 Graham D Y, Malaty H M, Evans D G. et al . Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status.  Gastroenterology. 1991;  100 (6) 1495-1501
• 8 Malaty H M, Evans D G, Evans D J. et al . Helicobacter pylori in Hispanics: comparison with blacks and whites of similar age and socioeconomic class.  Gastroenterology. 1992;  103 (3) 813-816
• 9 Malaty H M, Engstrand Jr L, Pedersen N L. et al . Helicobacter pylori infection: genetic and environmental influences. A study of twins.  Ann Intern Med. 1994;  120 (12) 982-986
• 10 Perez-Perez G I, Olivares A Z, Foo F Y. et al . Seroprevalence of Helicobacter pylori in New York City populations originating in East Asia.  J Urban Health. 2005;  82 (3) 510-516
• 11 Malaty H M, Kim J G, Kim S D. et al . Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults.  Am J Epidemiol. 1996;  143 (3) 257-262
• 12 Banatvala N, Mayo K, Megraud F. et al . The cohort effect and Helicobacter pylori.  J Infect Dis. 1993;  168 (1) 219-221
• 13 Roosendaal R, Kuipers E J, Buitenwerf J. et al . Helicobacter pylori and the birth cohort effect: evidence of a continuous decrease of infection rates in childhood.  Am J Gastroenterol. 1997;  92 (9) 1480-1482
• 14 al-Moagel M A, Evans D G, Abdulghani M E. et al . Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudia Arabia, and comparison of those with and without upper gastrointestinal symptoms.  Am J Gastroenterol. 1990;  85 (8) 944-948
• 15 Grimm W, Fischbach W. Helicobacter pylori infection in children and juveniles: an epidemiological study on prevalence, socio-economic factors and symptoms.  Dtsch Med Wochenschr. 2003;  128 (37) 1878-1883
• 16 Rothenbacher D, Bode G, Berg G. et al . Prevalence and determinants of Helicobacter pylori infection in preschool children: a population-based study from Germany.  Int J Epidemiol. 1998;  27 (1) 135-141
• 17 Brenner H, Weyermann M, Rothenbacher D. Clustering of Helicobacter pylori infection in couples: differences between high- and low-prevalence population groups.  Ann Epidemiol. 2006;  16 (7) 516-520
• 18 Kumagai T, Malaty H M, Graham D Y. et al . Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study.  J Infect Dis. 1998;  178 (3) 717-721
• 19 Tkachenko M A, Zhannat N Z, Erman L V. et al . Dramatic Changes in the Prevalence of Helicobacter pylori Infection During Childhood: A 10-year Follow-up Study in Russia.  J Pediatr Gastroenterol Nutr. 2007;  45 (4) 428-432
• 20 Parsonnet J. The incidence of Helicobacter pylori infection.  Aliment Pharmacol Ther. 1995;  9 (Suppl 2) 45-51
• 21 Parsonnet J, Shmuely H, Haggerty T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults.  Jama. 1999;  282 (23) 2240-2245
• 22 Leung W K, Siu K L, Kwok C K. et al . Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission.  Am J Gastroenterol. 1999;  94 (10) 2881-2884
• 23 Laporte R, Pernes P, Pronnier P. et al . Acquisition of Helicobacter pylori infection after outbreaks of gastroenteritis: prospective cohort survey in institutionalised young people.  Bmj. 2004;  329 (7459) 204-205
• 24 Handt L K, Fox J G, Dewhirst F E. et al . Helicobacter pylori isolated from the domestic cat: public health implications.  Infect Immun. 1994;  62 (6) 2367-2374
• 25 Dore M P, Sepulveda A R, Osato M S. et al . Helicobacter pylori in sheep milk.  Lancet. 1999;  354 (9173) 132
• 26 Dore M P, Sepulveda A R, El-Zimaity H. et al . Isolation of Helicobacter pylori from sheep-implications for transmission to humans.  Am J Gastroenterol. 2001;  96 (5) 1396-1401
• 27 Rocha G A, Rocha A M, Silva L D. et al . Transmission of Helicobacter pylori infection in families of preschool-aged children from Minas Gerais, Brazil.  Trop Med Int Health. 2003;  8 (11) 987-991
• 28 Rothenbacher D, Winkler M, Gonser T. et al . Role of infected parents in transmission of helicobacter pylori to their children.  Pediatr Infect Dis J. 2002;  21 (7) 674-679
• 29 Kivi M, Johansson A L, Reilly M. et al . Helicobacter pylori status in family members as risk factors for infection in children.  Epidemiol Infect. 2005;  133 (4) 645-652
• 30 Tindberg Y, Bengtsson C, Granath F. et al . Helicobacter pylori infection in Swedish school children: lack of evidence of child-to-child transmission outside the family.  Gastroenterology. 2001;  121 (2) 310-316
• 31 Han S R, Zschausch H C, Meyer H G. et al . Helicobacter pylori: clonal population structure and restricted transmission within families revealed by molecular typing.  J Clin Microbiol. 2000;  38 (10) 3646-3651
• 32 Kivi M, Tindberg Y, Sorberg M. et al . Concordance of Helicobacter pylori strains within families.  J Clin Microbiol. 2003;  41 (12) 5604-5608
• 33 Mendall M A, Goggin P M, Molineaux N. et al . Childhood living conditions and Helicobacter pylori seropositivity in adult life.  Lancet. 1992;  339 (8798) 896-897
• 34 Goodman K J, Correa P. Transmission of Helicobacter pylori among siblings.  Lancet. 2000;  355 (9201) 358-362
• 35 Rowland M, Daly L, Vaughan M. et al . Age-specific incidence of Helicobacter pylori.  Gastroenterology. 2006;  130 (1) 65-72; quiz 211
• 36 Goodman K J, Correa P, Tengana Aux H J. et al . Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways.  Am J Epidemiol. 1996;  144 (3) 290-299
• 37 Glynn M K, Friedman C R, Gold B D. et al . Seroincidence of Helicobacter pylori infection in a cohort of rural Bolivian children: acquisition and analysis of possible risk factors.  Clin Infect Dis. 2002;  35 (9) 1059-1065
• 38 Aguemon B D, Struelens M J, Massougbodji A. et al . Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations.  Clin Microbiol Infect. 2005;  11 (8) 611-617
• 39 Klein P D, Graham D Y, Gaillour A. et al . Water source as risk factor for Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group.  Lancet. 1991;  337 (8756) 1503-1506
• 40 Hulten K, Han S W, Enroth H. et al . Helicobacter pylori in the drinking water in Peru.  Gastroenterology. 1996;  110 (4) 1031-1035
• 41 Lu Y, Redlinger T E, Avitia R. et al . Isolation and genotyping of Helicobacter pylori from untreated municipal wastewater.  Appl Environ Microbiol. 2002;  68 (3) 1436-1439
• 42 Tomb J F, White O, Kerlavage A R. et al . The complete genome sequence of the gastric pathogen Helicobacter pylori.  Nature. 1997;  388 (6642) 539-547
• 43 Wheeldon T U, Hoang T T, Phung D C. et al . Long-term follow-up of Helicobacter pylori eradication therapy in Vietnam: reinfection and clinical outcome.  Aliment Pharmacol Ther. 2005;  21 (8) 1047-1053
• 44 Feydt-Schmidt A, Kindermann A, Konstantopoulos N. et al . Reinfection rate in children after successful Helicobacter pylori eradication.  Eur J Gastroenterol Hepatol. 2002;  14 (10) 1119-1123
• 45 Svennerholm A M, Lundgren A. Progress in vaccine development against Helicobacter pylori.  FEMS Immunol Med Microbiol. 2007;  50 (2) 146-156
• 46 Wilson K T, Crabtree J E. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies.  Gastroenterology. 2007;  133 (1) 288-308
• 47 Kivi M, Tindberg Y. Helicobacter pylori occurrence and transmission: a family affair?.  Scand J Infect Dis. 2006;  38 (6 – 7) 407-417
• 48 Kuepper-Nybelen J, Thefeld W, Rothenbacher D. et al . Patterns of alcohol consumption and Helicobacter pylori infection: results of a population-based study from Germany among 6545 adults.  Aliment Pharmacol Ther. 2005;  21 (1) 57-64
• 49 Metzger W G, Mansouri E, Kronawitter M. et al . Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers.  Vaccine. 2004;  22 (17 – 18) 2273-2277
• 50 Graham D Y, Opekun A R, Osato M S. et al . Challenge model for Helicobacter pylori infection in human volunteers.  Gut. 2004;  53 (9) 1235-1243
• 51 Losonsky G A, Kotloff K L, Walker R I. B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LT(R192G) in H pylori seronegative individuals.  Vaccine. 2003;  21 (5 – 6) 562-565
• 52 Banerjee S, Medina-Fatimi A, Nichols R. et al . Safety and efficacy of low dose Escherichia coli enterotoxin adjuvant for urease based oral immunisation against Helicobacter pylori in healthy volunteers.  Gut. 2002;  51 (5) 634-640
• 53 Rupnow M F, Shachter R D, Owens D K. et al . Quantifying the population impact of a prophylactic Helicobacter pylori vaccine.  Vaccine. 2001;  20 (5 – 6) 879-885
• 54 Kotloff K L, Sztein M B, Wasserman S S. et al . Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection.  Infect Immun. 2001;  69 (6) 3581-3590
• 55 Bumann D, Metzger W G, Mansouri E. et al . Safety and immunogenicity of live recombinant Salmonella enterica serovar Typhi Ty21a expressing urease A and B from Helicobacter pylori in human volunteers.  Vaccine. 2001;  20 (5 – 6) 845-852
• 56 Angelakopoulos H, Hohmann E L. Pilot study of phoP/phoQ-deleted Salmonella terica serovar typhimurium expressing Helicobacter pylori urease in adult volunteers.  Infect Immun. 2000;  68 (4) 2135-2141
• 57 Rupnow M F, Owens D K, Shachter R. et al . Helicobacter pylori vaccine development and use: a cost-effectiveness analysis using the Institute of Medicine Methodology.  Helicobacter. 1999;  4 (4) 272-280
• 58 Michetti P, Kreiss C, Kotloff K L. et al . Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults.  Gastroenterology. 1999;  116 (4) 804-812
• 59 DiPetrillo M D, Tibbetts T, Kleanthous H. et al . Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers.  Vaccine. 1999;  18 (5 – 6) 449-459
• 60 Forman D, Newell D G, Fullerton F. et al . Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.  Bmj. 1991;  302 (6788) 1302-1305
• 61 Forman D, Sitas F, Newell D G. et al . Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China.  Int J Cancer. 1990;  46 (4) 608-611
• 62 Stolte M, Eidt S. Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori?.  J Clin Pathol. 1989;  42 (12) 1269-1271
• 63 NIH Consensus Conference . Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease.  Jama. 1994;  272 (1) 65-69
• 64 Peura D A, Graham D Y. Helicobacter pylori: consensus reached: peptic ulcer is on the way to becoming an historic disease.  Am J Gastroenterol. 1994;  89 (8) 1137-1139
• 65 Nomura A, Stemmermann G N, Chyou P H. et al . Helicobacter pylori infection and the risk for duodenal and gastric ulceration.  Ann Intern Med. 1994;  120 (12) 977-981
• 66 Huang J Q, Sridhar S, Chen Y. et al . Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer.  Gastroenterology. 1998;  114 (6) 1169-1179
• 67 Danesh J. Helicobacter pylori infection and gastric cancer: systematic review of the epidemiological studies.  Aliment Pharmacol Ther. 1999;  13 (7) 851-856
• 68 Eslick G D, Lim L L, Byles J E. et al . Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis.  Am J Gastroenterol. 1999;  94 (9) 2373-2379
• 69 Xue F B, Xu Y Y, Wan Y. et al . Association of H. pylori infection with gastric carcinoma: a Meta analysis.  World J Gastroenterol. 2001;  7 (6) 801-804
• 70 Huang J Q, Zheng G F, Sumanac K. et al . Meta-analysis of the relationship between cagA seropositivity and gastric cancer.  Gastroenterology. 2003;  125 (6) 1636-1644
• 71 Helicobacter and Cancer Collaborative Group . Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts.  Gut. 2001;  49 (3) 347-353
• 72 Brenner H, Arndt V, Stegmaier C. et al . Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer?.  Am J Epidemiol. 2004;  159 (3) 252-258
• 73 Parsonnet J, Hansen S, Rodriguez L. et al . Helicobacter pylori infection and gastric lymphoma.  N Engl J Med. 1994;  330 (18) 1267-1271
• 74 Lehours P, Dupouy S, Bergey B. et al . Identification of a genetic marker of Helicobacter pylori strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type.  Gut. 2004;  53 (7) 931-937
• 75 Solnick J V, Schauer D B. Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases.  Clin Microbiol Rev. 2001;  14 (1) 59-97
• 76 Morgner A, Lehn N, Andersen L P. et al . Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection.  Gastroenterology. 2000;  118 (5) 821-828
• 77 Noone P A, Waclawski E R, Watt A D. Are endoscopy nurses at risk of infection with Helicobacter pylori from their work?.  Occup Med. 2006;  56 (2) 122-128
• 78 Mastromarino P, Conti C, Donato K. et al . Does hospital work constitute a risk factor for Helicobacter pylori infection?.  J Hosp Infect. 2005;  60 (3) 261-268
• 79 Matsuda R, Morizane T. Helicobacter pylori infection in dental professionals: a 6-year prospective study.  Helicobacter. 2005;  10 (4) 307-311
• 80 Kim N, Lim S H, Lee K H. et al . Seroconversion of Helicobacter pylori in Korean male employees.  Scand J Gastroenterol. 2005;  40 (9) 1021-1027
• 81 Braden B, Duan L P, Caspary W F. et al . Endoscopy is not a risk factor for Helicobacter pylori infection– but medical practice is.  Gastrointest Endosc. 1997;  46 (4) 305-310
• 82 Cutler A F, Havstad S, Ma C K. et al . Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection.  Gastroenterology. 1995;  109 (1) 136-141
• 83 Thijs J C, Zwet A A, Thijs W J. et al . Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy, without selecting a single test as the gold standard.  Am J Gastroenterol. 1996;  91 (10) 2125-2129
• 84 Laheij R J, Boer de W A, Jansen J B. et al . Diagnostic performance of biopsy-based methods for determination of Helicobacter pylori infection without a reference standard.  J Clin Epidemiol. 2000;  53 (7) 742-746
• 85 Juttner van S, Vieth M, Miehlke S. et al . Reliable detection of macrolide-resistant Helicobacter pylori via fluorescence in situ hybridization in formalin-fixed tissue.  Mod Pathol. 2004;  17 (6) 684-689
• 86 Lottspeich C, Schwarzer A, Panthel K. et al . Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens from symptomatic children.  J Clin Microbiol. 2007;  45 (6) 1718-1722
• 87 Gisbert J P, Pajares J M. Review article: C-urea breath test in the diagnosis of Helicobacter pylori infection – a critical review.  Aliment Pharmacol Ther. 2004;  20 (10) 1001-1017
• 88 Leodolter A, Dominguez-Munoz J E, Arnim von U. et al . Validity of a modified 13C-urea breath test for pre- and posttreatment diagnosis of Helicobacter pylori infection in the routine clinical setting.  Am J Gastroenterol. 1999;  94 (8) 2100-2104
• 89 Gisbert J P, Morena de la F, Abraira V. Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis.  Am J Gastroenterol. 2006;  101 (8) 1921-1930
• 90 Feldman R A, Deeks J J, Evans S J. Multi-laboratory comparison of eight commercially available Helicobacter pylori serology kits. Helicobacter pylori Serology Study Group.  Eur J Clin Microbiol Infect Dis. 1995;  14 (5) 428-433
• 91 Loy C T, Irwig L M, Katelaris P H. et al . Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis.  Am J Gastroenterol. 1996;  91 (6) 1138-1144
• 92 Bayerdorffer E, Oertel H, Lehn N. et al . Topographic association between active gastritis and Campylobacter pylori colonisation.  J Clin Pathol. 1989;  42 (8) 834-839
• 93 Dixon M F, Genta R M, Yardley J H. et al . Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994.  Am J Surg Pathol. 1996;  20 (10) 1161-1181
• 94 Stolte M, Muller H, Talley N J. et al . In patients with Helicobacter pylori gastritis and functional dyspepsia, a biopsy from the incisura angularis provides useful diagnostic information.  Pathol Res Pract. 2006;  202 (6) 405-413
• 95 Guidelines for clinical trials in Helicobacter pylori infection. Working Party of the European Helicobacter pylori Study Group.  Gut. 1997;  41 (Suppl 2) S1-S9
• 96 Megraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing.  Clin Microbiol Rev. 2007;  20 (2) 280-322
• 97 Woo J S, El Zimaity H M, Genta R M. et al . The best gastric site for obtaining a positive rapid ureas test.  Helicobacter. 1996;  1 (4) 256-259
• 98 Tepes B. Comparison of two invasive diagnostic tests for Helicobacter pylori after antimicrobial therapy.  Scand J Gastroenterol. 2007;  42 (3) 330-332
• 99 IJzendoorn M C, Laheij R J, Boer de W A. et al . The importance of corpus biopsies for the determination of Helicobacter pylori infection.  Neth J Med. 2005;  63 (4) 141-145
• 100 Leodolter van A, Vaira D, Bazzoli F. et al . European multicentre validation trial of two new non-invasive tests for the detection of Helicobacter pylori antibodies: urine-based ELISA and rapid urine test.  Aliment Pharmacol Ther. 2003;  18 (9) 927-931
• 101 Hackelsberger A, Schultze V, Peitz U. et al . Performance of a rapid whole blood test for Helicobacter pylori in primary care: a German multicenter study.  Helicobacter. 1998;  3 (3) 179-183
• 102 Peitz U, Baumann M, Tillenburg B. et al . (Insufficient validity of a rapid blood test for diagnosis of Helicobacter pylori infection).  Med Klin. 2001;  96 (12) 703-707
• 103 Hoang T T, Rehnberg A S, Wheeldon T U. et al . Comparison of the performance of serological kits for Helicobacter pylori infection with European and Asian study populations.  Clin Microbiol Infect. 2006;  12 (11) 1112-1117
• 104 Suerbaum S, Achtman M. Helicobacter pylori: recombination, population structure and human migrations.  Int J Med Microbiol. 2004;  294 (2 – 3) 133-139
• 105 Ekstrom A M, Held M, Hansson L E. et al . Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection.  Gastroenterology. 2001;  121 (4) 784-791
• 106 Capurso G, Carnuccio A, Lahner E. et al . Corpus-predominant gastritis as a risk factor for false-negative 13C-urea breath test results.  Aliment Pharmacol Ther. 2006;  24 (10) 1453-1460
• 107 Kokkola A, Rautelin H, Puolakkainen P. et al . Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea breath test, and serology.  Scand J Gastroenterol. 2000;  35 (2) 138-141
• 108 Korstanje A, Eeden van S, Offerhaus G J. et al . The 13carbon urea breath test for the diagnosis of Helicobacter pylori infection in subjects with atrophic gastritis: evaluation in a primary care setting.  Aliment Pharmacol Ther. 2006;  24 (4) 643-650
• 109 Lahner E, Vaira D, Figura N. et al . Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritis.  Helicobacter. 2004;  9 (5) 436-442
• 110 Lehours P, Ruskone-Fourmestraux A, Lavergne A. et al . Which test to use to detect Helicobacter pylori infection in patients with low-grade gastric mucosa-associated lymphoid tissue lymphoma?.  Am J Gastroenterol. 2003;  98 (2) 291-295
• 111 Schilling D, Jakobs R, Peitz U. et al . Diagnostic accuracy of (13)C-urea breath test in the diagnosis of Helicobacter pylori infection in patients with partial gastric resection due to peptic ulcer disease: a prospective multicenter study.  Digestion. 2001;  63 (1) 8-13
• 112 Laine L A, Nathwani R A, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later.  Gastrointest Endosc. 2005;  62 (6) 853-859
• 113 Lee J M, Breslin N P, Fallon C. et al . Rapid urease tests lack sensitivity in Helicobacter pylori diagnosis when peptic ulcer disease presents with bleeding.  Am J Gastroenterol. 2000;  95 (5) 1166-1170
• 114 Peitz U, Leodolter A, Wex T. et al . Diagnostics of Helicobacter pylori infection in patients with peptic ulcer bleeding.  Z Gastroenterol. 2004;  42 (2) 141-146
• 115 Gisbert J P, Abraira V. Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis.  Am J Gastroenterol. 2006;  101 (4) 848-863
• 116 Schilling D, Demel A, Adamek H E. et al . A negative rapid urease test is unreliable for exclusion of Helicobacter pylori infection during acute phase of ulcer bleeding. A prospective case control study.  Dig Liver Dis. 2003;  35 (4) 217-221
• 117 Brandi G, Biavati B, Calabrese C. et al . Urease-positive bacteria other than Helicobacter pylori in human gastric juice and mucosa.  Am J Gastroenterol. 2006;  101 (8) 1756-1761
• 118 Urita Y, Hike K, Torii N. et al . Influence of urease activity in the intestinal tract on the results of 13C-urea breath test.  J Gastroenterol Hepatol. 2006;  21 (4) 744-747
• 119 MacOni G, Vago L, Galletta G. et al . Is routine histological evaluation an accurate test for Helicobacter pylori infection?.  Aliment Pharmacol Ther. 1999;  13 (3) 327-331
• 120 Stolte M, Wellens E, Bethke B. et al . Helicobacter heilmannii (formerly Gastrospirillum hominis) gastritis: an infection transmitted by animals?.  Scand J Gastroenterol. 1994;  29 (12) 1061-1064
• 121 Chey W D, Woods M, Scheiman J M. et al . Lansoprazole and ranitidine affect the accuracy of the 14C-urea breath test by a pH-dependent mechanism.  Am J Gastroenterol. 1997;  92 (3) 446-450
• 122 Laine L, Estrada R, Trujillo M. et al . Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori.  Ann Intern Med. 1998;  129 (7) 547-550
• 123 Gatta L, Vakil N, Ricci C. et al . Effect of proton pump inhibitors and antacid therapy on 13C urea breath tests and stool test for Helicobacter pylori infection.  Am J Gastroenterol. 2004;  99 (5) 823-829
• 124 Graham D Y, Opekun A R, Hammoud F. et al . Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors.  Am J Gastroenterol. 2003;  98 (5) 1005-1009
• 125 Levine A, Shevah O, Shabat-Sehayek V. et al . Masking of 13C urea breath test by proton pump inhibitors is dependent on type of medication: comparison between omeprazole, pantoprazole, lansoprazole and esomeprazole.  Aliment Pharmacol Ther. 2004;  20 (1) 117-122
• 126 Mana F, Van Laere W, Bossuyt A. et al . The early effect of proton pump inhibitor therapy on the accuracy of the 13C-urea breath test.  Dig Liver Dis. 2005;  37 (1) 28-32
• 127 Manes G, Balzano A, Iaquinto G. et al . Accuracy of the stool antigen test in the diagnosis of Helicobacter pylori infection before treatment and in patients on omeprazole therapy.  Aliment Pharmacol Ther. 2001;  15 (1) 73-79
• 128 Malfertheiner P, Megraud F, O’Morain C. et al . Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.  Gut. 2007;  56 (6) 772-781
• 129 Stolte M, Stadelmann O, Bethke B. et al . Relationships between the degree of Helicobacter pylori colonisation and the degree and activity of gastritis, surface epithelial degeneration and mucus secretion.  Z Gastroenterol. 1995;  33 (2) 89-93
• 130 Grimley C E, Holder R L, Loft D E. et al . Helicobacter pylori-associated antibodies in patients with duodenal ulcer, gastric and oesophageal adenocarcinoma.  Eur J Gastroenterol Hepatol. 1999;  11 (5) 503-509
• 131 Han S R, Schneider T, Loos M. et al . One-step polymerase chain reaction-based typing of Helicobacter pylori vacA gene: association with gastric histopathology.  Med Microbiol Immunol. 1999;  188 (3) 131-138
• 132 Lamarque D, Gilbert T, Roudot-Thoraval F. et al . Seroprevalence of eight Helicobacter pylori antigens among 182 patients with peptic ulcer, MALT gastric lymphoma or non-ulcer dyspepsia. Higher rate of seroreactivity against CagA and 35-kDa antigens in patients with peptic ulcer originating from Europe and Africa.  Eur J Gastroenterol Hepatol. 1999;  11 (7) 721-726
• 133 Plummer M, Doorn L J, Franceschi van S. et al . Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions.  J Natl Cancer Inst. 2007;  99 (17) 1328-1334
• 134 Scholte G H, Doorn L J, Cats van A. et al . Genotyping of Helicobacter pylori in paraffin-embedded gastric biopsy specimens: relation to histological parameters and effects on therapy.  Am J Gastroenterol. 2002;  97 (7) 1687-1695
• 135 Kodama K, Ito A, Nishizono A. et al . Divergence of virulence factors of Helicobacter pylori among clinical isolates does not correlate with disease specificity.  J Gastroenterol. 1999;  34 (Suppl 11) 6-9
• 136 Breuer T, Graham D Y. Costs of diagnosis and treatment of Helicobacter pylori infection: when does choosing the treatment regimen based on susceptibility testing become cost effective?.  Am J Gastroenterol. 1999;  94 (3) 725-729
• 137 Romano M, Marmo R, Cuomo A. et al . Pretreatment antimicrobial susceptibility testing is cost saving in the eradication of Helicobacter pylori.  Clin Gastroenterol Hepatol. 2003;  1 (4) 273-278
• 138 Marzio L, Coraggio D, Capodicasa S. et al . Role of the preliminary susceptibility testing for initial and after failed therapy of Helicobacter pylori infection with levofloxacin, amoxicillin, and esomeprazole.  Helicobacter. 2006;  11 (4) 237-242
• 139 Malfertheiner P, Peitz U, Wolle K. et al . Helicobacter pylori infection – an update for 2004.  Dtsch Med Wochenschr. 2004;  129 (34 – 35) 1821-1826
• 140 Best L M, Haldane D J, Keelan M. et al . Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods.  Antimicrob Agents Chemother. 2003;  47 (10) 3138-3144
• 141 Grignon B, Tankovic J, Megraud F. et al . Validation of diffusion methods for macrolide susceptibility testing of Helicobacter pylori.  Microb Drug Resist. 2002;  8 (1) 61-66
• 142 Perna F, Gatta L, Figura N. et al . Susceptibility of Helicobacter pylori to metronidazole.  Am J Gastroenterol. 2003;  98 (10) 2157-2161
• 143 Ford A C, Delaney B C, Forman D. et al . Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients.  Cochrane Database Syst Rev. 2006;  2 CD003840
• 144 Laine L, Hopkins R J, Girardi L S. Has the impact of Helicobacter pylori therapy on ulcer recurrence in the United States been overstated? A meta-analysis of rigorously designed trials.  Am J Gastroenterol. 1998;  93 (9) 1409-1415
• 145 Leodolter A, Kulig M, Brasch H. et al . A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer.  Aliment Pharmacol Ther. 2001;  15 (12) 1949-1958
• 146 Liu C C, Lee C L, Chan C C. et al . Maintenance treatment is not necessary after Helicobacter pylori eradication and healing of bleeding peptic ulcer: a 5-year prospective, randomized, controlled study.  Arch Intern Med. 2003;  163 (17) 2020-2024
• 147 Malfertheiner P, Megraud F, O’Morain C. et al . Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.  Gut. 2007;  56 (6) 772-781
• 148 Sharma V K, Sahai A V, Corder F A. et al . Helicobacter pylori eradication is superior to ulcer healing with or without maintenance therapy to prevent further ulcer haemorrhage.  Aliment Pharmacol Ther. 2001;  15 (12) 1939-1947
• 149 Sonnenberg A, Olson C A, Zhang J. The effect of antibiotic therapy on bleeding from duodenal ulcer.  Am J Gastroenterol. 1999;  94 (4) 950-954
• 150 Blum A L TNO. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group.  N Engl J Med. 1998;  339 (26) 1875-1881
• 151 Froehlich F, Gonvers J J, Wietlisbach V. et al . Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia.  Am J Gastroenterol. 2001;  96 (8) 2329-2336
• 152 Kamada T, Haruma K, Hata J. et al . The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis.  Aliment Pharmacol Ther. 2003;  18 (2) 245-252
• 153 Koskenpato J. Helicobacter pylori eradication and standardized 3-month omeprazole therapy in functional dyspepsia.  The American journal of gastroenterology. 2001;  96 (10) 2866-2872
• 154 Malfertheiner P. Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia.  Alimentary pharmacology & therapeutics. 2003;  18 (6) 615-625
• 155 McColl K. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.  The New England journal of medicine. 1998;  339 (26) 1869-1874
• 156 McNamara D, Buckley M, Gilvarry J. et al . Does Helicobacter pylori eradication affect symptoms in nonulcer dyspepsia: a 5-year follow-up study.  Helicobacter. 2002;  7 (5) 317-321
• 157 Talley N J VN. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia.  The New England journal of medicine. 1999;  341 (15) 1106-1111
• 158 Veldhuyzen v Z, Fedorak R N, Lambert J. et al . Absence of symptomatic benefit of lansoprazole, clarithromycin, and amoxicillin triple therapy in eradication of Helicobacter pylori positive, functional (nonulcer) dyspepsia.  Am J Gastroenterol. 2003;  98 (9) 1963-1969
• 159 Hudson N, Brydon W G, Eastwood M A. et al . Successful Helicobacter pylori eradication incorporating a one-week antibiotic regimen.  Aliment Pharmacol Ther. 1995;  9 (1) 47-50
• 160 Loo V G, Poirier L, Miller M A. et al . A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile-Associated Diarrhea with High Morbidity and Mortality.  N Engl J Med. 2005;  353 (23) 2442-2449
• 161 Delaney J A, Dial S, Barkun A. et al . Antimicrobial drugs and community-acquired Clostridium difficile-associated disease, UK.  Emerg Infect Dis. 2007;  13 (5) 761-763
• 162 Dial S, Delaney J AC, Barkun A N. et al . Use of Gastric Acid-Suppressive Agents and the Risk of Community-Acquired Clostridium difficile-Associated Disease.  JAMA. 2005;  294 (23) 2989-2995
• 163 Drossman D A, Dumitrascu D L. Rome III: New standard for functional gastrointestinal disorders.  J Gastrointestin Liver Dis. 2006;  15 (3) 237-241
• 164 Chiba N. Economic evaluation of Helicobacter pylori eradication in the CADET-Hp randomized controlled trial of H. pylori-positive primary care patients with uninvestigated dyspepsia.  Alimentary pharmacology & therapeutics. 2004;  19 (3) 349-358
• 165 Talley N J. American Gastroenterological Association medical position statement: evaluation of dyspepsia.  Gastroenterology. 2005;  129 (5) 1753-1755
• 166 Moayyedi P, Soo S, Deeks J. et al . Eradication of Helicobacter pylori for non-ulcer dyspepsia.  Cochrane Database Syst Rev. 2006;  2 CD002096
• 167 Vakil N. Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal reflux disease in Western patients with non-ulcer dyspepsia.  Alimentary pharmacology & therapeutics. 2006;  24 (1) 55-63
• 168 Wu J C, Chan F K, Ching J Y. et al . Effect of Helicobacter pylori eradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomised trial.  Gut. 2004;  53 (2) 174-179
• 169 Labenz J, Blum A L, BayerdOrffer E. et al . Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis.  Gastroenterology. 1997;  112 (5) 1442-1447
• 170 Hamada H, Haruma K, Mihara M. et al . High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of hiatal hernia and corpus gastritis.  Aliment Pharmacol Ther. 2000;  14 (6) 729-735
• 171 Vakil N, Hahn B, McSorley D. Recurrent symptoms and gastro-oesophageal reflux disease in patients with duodenal ulcer treated for Helicobacter pylori infection.  Aliment Pharmacol Ther. 2000;  14 (1) 45-51
• 172 Laine L, Sugg J. Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies.  Am J Gastroenterol. 2002;  97 (12) 2992-2997
• 173 Vakil N, Talley N J, Stolte M. et al . Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal reflux disease in Western patients with non-ulcer dyspepsia.  Aliment Pharmacol Ther. 2006;  24 (1) 55-63
• 174 Pilotto A, Perri F, Leandro G. et al . Effect of Helicobacter pylori eradication on the outcome of reflux esophagitis and chronic gastritis in the elderly. A randomized, multicenter, eight-month study.  Gerontology. 2006;  52 (2) 99-106
• 175 Kuipers E J, Nelis G F, Klinkenberg-Knol E C. et al . Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial.  Gut. 2004;  53 (1) 12-20
• 176 Malfertheiner P, Dent J, Zeijlon L. et al . Impact of Helicobacter pylori eradication on heartburn in patients with gastric or duodenal ulcer disease – results from a randomized trial programme.  Aliment Pharmacol Ther. 2002;  16 (8) 1431-1442
• 177 Moayyedi P, Bardhan C, Young L. et al . Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease.  Gastroenterology. 2001;  121 (5) 1120-1126
• 178 Schenk B E, Kuipers E J, Nelis G F. et al . Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy.  Gut. 2000;  46 (5) 615-621
• 179 Lundell L, Miettinen P, Myrvold H E. et al . Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group.  Gastroenterology. 1999;  117 (2) 319-326
• 180 Franchini M, Cruciani M, Mengoli C. et al . Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis.  J Antimicrob Chemother. 2007;  60 (2) 237-246
• 181 Chen L H, Luo H S. Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis.  World J Gastroenterol. 2007;  13 (40) 5380-5383
• 182 Tsutsumi Y, Kanamori H, Yamato H. et al . Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura.  Ann Hematol. 2005;  84 (12) 807-811
• 183 Suzuki T, Matsushima M, Masui A. et al . Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpura – a randomized controlled trial.  Am J Gastroenterol. 2005;  100 (6) 1265-1270
• 184 Emilia G, Longo G, Luppi M. et al . Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura.  Blood. 2001;  97 (3) 812-814
• 185 Emilia G, Luppi M, Zucchini P. et al . Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles.  Blood. 2007;  110 (12) 3833-3841
• 186 Yoshimura M, Hirai M, Tanaka N. et al . Remission of severe anemia persisting for over 20 years after eradication of Helicobacter pylori in cases of Menetrier’s disease and atrophic gastritis: Helicobacter pylori as a pathogenic factor in iron-deficiency anemia.  Intern Med. 2003;  42 (10) 971-977
• 187 Kawasaki M, Hizawa K, Aoyagi K. et al . Menetrier’s disease associated with Helicobacter pylori infection: resolution of enlarged gastric folds and hypoproteinemia after antibacterial treatment.  Am J Gastroenterol. 1997;  92 (10) 1909-1912
• 188 Yamada M, Sumazaki R, Adachi H. et al . Resolution of protein-losing hypertrophic gastropathy by eradication of Helicobacter pylori.  Eur J Pediatr. 1997;  156 (3) 182-185
• 189 Bayerdörffer E, Ritter M M, Hatz R. et al . Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori – is Helicobacter pylori a pathogenic factor in Menetrier’s disease?.  Gut. 1994;  35 (5) 701-704
• 190 Madisch A, Miehlke S, Neuber F. et al . Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy – a randomized, double-blind, placebo-controlled multicentre trial.  Aliment Pharmacol Ther. 2006;  23 (4) 473-479
• 191 Chen L H, Luo H S. Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis.  World J Gastroenterol. 2007;  13 (40) 5380-5383
• 192 Choe Y H, Kim S K, Son B K. et al . Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents.  Helicobacter. 1999;  4 (2) 135-139
• 193 Wotherspoon A C, Ortiz-Hidalgo C, Falzon M R. et al . Helicobacter pylori associated gastritis and primary B-cell gastric lymphoma.  Lancet. 1991;  338 1175-1176
• 194 Stolte M, Eidt S. Lymphoid follicles in the antral mucosa: immune response to Campylobacter pylori.  J Clin Pathol. 1989;  42 1269-1271
• 195 Stolte M. H. pylori and gastric MALT lymphoma.  Lancet. 1992;  339 745-746
• 196 Doglioni C, Wotherspoon A C, Moschini A. et al . High incidence of primary gastric lymphoma in northeastern Italy.  Lancet. 1992;  339 1175-1176
• 197 Zaki M, Schubert M L. Helicobacter pylori and gastric lymphoma.  Gastroenterology. 1995;  108 610-612
• 198 Hussell T, Isaacson P G, Crabtree J E. et al . The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori.  Lancet. 1993;  342 571-574
• 199 Parsonnet J, Freidman G D, Vandersteen D P. et al . Helicobacter pylori infection and the risk of gastric carcinoma.  N Engl J Med. 1991;  325 1127-1131
• 200 Isaacson P G, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue.  Histopathology. 1987;  11 44-49
• 201 Myhre M J, Isaacson P G. Primary B-cell gastric lymphoma – a reassessment of its histogenesis.  J Pathol. 1987;  152 1-11
• 202 El-Zimaity H M, Wotherspoon A, Jong de D. Houston MALT lymphoma Workshop. Interobserver variation in the histopathological assessment of malt/malt lymphoma: towards a consensus.  Blood Cells Mol Dis. 2005;  34 6-16
• 203 Harris N L, Jaffe E S, Stein H. et al . A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group.  Blood. 1994;  84 1361-1392
• 204 Harris N L, Jaffe E S, Diebold J. et al . World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting – Airlie House, Virginia, November 1997.  J Clin Oncol. 1999;  17 3835-3849
• 205 Lymphoma Classification Project . A clinical evaluation of the international lymphoma study group classification of non-Hodgkin’s lymphoma.  Blood. 1997;  89 3909-3918
• 206 Musshoff K. Klinische Stadieneinteilung der nicht-Hodgkin-Lymphome.  Strahlentherapie. 1977;  153 218-222
• 207 Radaszkiewicz T, Dragosics B, Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated tissue: Factors relevant to prognosis.  Gastroenterology. 1992;  102 1628-1638
• 208 Steinbach G, Ford R, Glober G. et al . Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: an uncontrolled trial.  Ann Intern Med. 1999;  131 88-95
• 209 Shimodaira M, Tsukamoto Y, Niwa Y. et al . A proposed staging system for primary gastric lymphoma.  Cancer. 1994;  73 2709-2715
• 210 Ruskoné-Fourmestraux A, Dragosics B, Morgner A. et al . Paris staging system for primary gastrointestinal lymphomas.  Gut. 2003;  52 912-913
• 211 Morgner A, Schmelz R, Thiede C. et al . Therapy of gastric mucosa associated lymphoid tissue lymphoma.  World J Gastroenterol. 2007;  13 3554-3566
• 212 Bayerdorffer E, Neubauer A, Rudolph B. et al . Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group.  Lancet. 1995;  345 1591-1594
• 213 Neubauer A, Thiede C, Morgner A. et al . Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma.  J Natl Cancer Inst. 1997;  89 1350-1355
• 214 Wündisch T, Thiede C, Morgner A. et al . Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication.  J Clin Oncol. 2005;  23 8018-8024
• 215 Koch P, Probst A, Berdel W E. et al . Treatment results in localized primary gastric lymphoma: data of patients registered within the German multicenter study (GIT NHL 02 / 96).  J Clin Oncol. 2005;  23 7050-7059
• 216 Koch P, del Valle F, Berdel W E. et al . German Multicenter Study Group. Primary gastrointestinal non-Hodgkin’s lymphoma: II. Combined surgical and conservative or conservative management only in localized gastric lymphoma – results of the prospective German Multicenter Study GIT NHL 01 / 92.  J Clin Oncol. 2001;  19 3874-3883
• 217 Fischbach W, Dragosics B, Kolve-Goebeler M E. et al . Primary gastric B-cell lymphoma: results of a prospective multicenter study. The German-Austrian Gastrointestinal Lymphoma Study Group.  Gastroenterology. 2000;  119 1191-1202
• 218 Raderer M, Wöhrer S, Streubel B. et al . Assessment of disease dissemination in gastric compared with extragastric mucosa-associated lymphoid tissue lymphoma using extensive staging: a single-center experience.  J Clin Oncol. 2006;  24 3136-3141
• 219 Flieger D, Keller R, May A. et al . Capsule endoscopy in gastrointestinal lymphomas.  Endoscopy. 2005;  37 1174-1180
• 220 Morgner A, Miehlke S, Fischbach W. et al . Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection.  J Clin Oncol. 2001;  19 2041-2048
• 221 Chen L T, Lin J T, Tai J J. et al . Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma.  J Natl Cancer Inst. 2005;  97 1345-1353
• 222 Chen L T, Lin J T, Shyu R Y. et al . Prospective study of Helicobacter pylori eradication therapy in stage I(E) high-grade mucosa-associated lymphoid tissue lymphoma of the stomach.  J Clin Oncol. 2001;  19 4245-4251
• 223 Boot H, Jong de D, Heerde van P. et al . Role of Helicobacter pylori eradication in high-grade MALT lymphoma.  Lancet. 1995;  346 448-449
• 224 Morgner A, Bayerdörffer E, Neubauer A. et al . Malignant tumours of the stomach: Gastric MALT lymphoma and Helicobacter pylori. In Marshall B (ed).  Gastroenterol Clin North Am. 2000;  29 593-607
• 225 Bayerdorffer E, Neubauer A, Rudolph B. et al . Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group.  Lancet. 1995;  345 1591-1594
• 226 Roggero E, Zucca E, Pinotti G. et al . Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue.  Ann Intern Med. 1996;  124 275-276
• 227 Neubauer A, Thiede C, Morgner A. et al . Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma.  J Natl Cancer Inst. 1997;  89 1350-1355
• 228 Steinbach G, Ford R, Glober G. et al . Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial.  Ann Intern Med. 1999;  131 88-95
• 229 Savio A, Zamboni G, Capelli P. et al . Relapse of low-grade gastric MALT lymphoma after Helicobacter pylori eradication: true relapse or persistence? Long-term post-treatment follow-up of a multicenter trial in the north-east of Italy and evaluation of the diagnostic protocol’s adequacy.  Recent Results Cancer Res. 2000;  156 116-124
• 230 Morgner A, Lehn N, Andersen L P. et al . Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection.  Gastroenterology. 2000;  118 821-828
• 231 Ruskone-Fourmestraux A, Lavergne A, Aegerter P H. et al . Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment.  Gut. 2001;  48 297-303
• 232 Nakamura S, Matsumoto T, Suekane H. et al . Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori.  Gut. 2001;  48 454-460
• 233 Stolte M, Bayerdorffer E, Morgner A. et al . Helicobacter and gastric MALT lymphoma.  Gut. 2002;  50 (Suppl 3) 19-24
• 234 Diz-Lois Palomares M T, Souto Ruzo J, Yanez Lopez J A. et al . Early-stage gastric MALT lymphomas: eradication of H. pylori and outcome.  Rev Esp Enferm Dig. 2002;  94 669-678
• 235 Fischbach W, Goebeler-Kolve M E, Dragosics B. et al . Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series.  Gut. 2004;  53 34-37
• 236 Wundisch T, Thiede C, Morgner A. et al . Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication.  J Clin Oncol. 2005;  23 8018-8024
• 237 Wundisch T, Mosch C, Neubauer A. et al . Helicobacter pylori eradication in gastric mucosa-associated lymphoid tissue lymphoma: Results of a 196-patient series.  Leuk Lymphoma. 2006;  47 2110-2114
• 238 Sackmann M, Morgner A, Rudolph B. et al . Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group.  Gastroenterology. 1997;  113 1087-1090
• 239 Fischbach W, Goebeler-Kolve M, Starostik P. et al . Minimal residual low-grade gastric MALT-type lymphoma after eradication of Helicobacter pylori.  Lancet. 2002;  360 547-548
• 240 Thiede C, Wundisch T, Alpen B. et al . German MALT Lymphoma Study Group. Long-term persistence of monoclonal B cells after cure of Helicobacter pylori infection and complete histologic remission in gastric mucosa-associated lymphoid tissue B-cell lymphoma.  J Clin Oncol. 2001;  19 1600-1609
• 241 Fischbach W, Goebeler M E, Ruskone-Fourmestraux A. et al . Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series.  Gut. 2007;  56 1685-1687
• 242 Ott G, Katzenberger T, Greiner A. et al . The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue (MALT-)type.  Cancer Res. 1997;  57 3944-3948
• 243 Auer I A, Gascoyne R D, Connors J M. et al . :t(11;18)(q21;q21) is the most common translocation in MALT lymphomas.  Ann Oncol. 1997;  8 979-985
• 244 Baens M, Maes B, Steyls A. et al . The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.  Am J Pathol. 2000;  156 1433-1439
• 245 Liu H, Ruskoné-Fourmestraux A, Lavergne-Slove A. et al . Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy.  Lancet. 2001;  357 39-40
• 246 Liu H, Ye H, Ruskoné-Fourmestraux A. et al . T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication.  Gastroenterology. 2002;  122 1286-1294
• 247 Alpen B, Neubauer A, Dierlamm J. et al . Translocation t(11;18) absent in early gastric marginal zone B-cell lymphoma of MALT type responding to eradication of Helicobacter pylori infection.  Blood. 2000;  95 4014-4015
• 248 Nakamura T, Nakamura S, Yonezumi M. et al . Helicobacter pylori and the t(11;18)(q21;q21) translocation in gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type.  Jpn J Cancer Res. 2000;  91 301-309
• 249 Ye H, Dogan A, Karran L. et al . BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.  Am J Pathol. 2000;  157 1147-1154
• 250 Sugiyama T, Asaka M, Nakamura T. et al . API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma.  Gastroenterology. 2001;  120 1884-1885
• 251 Raderer M, Streubel B, Wohrer S. et al . Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomas.  Gut. 2006;  55 616-618
• 252 Schechter N R, Yahalom J. Low-grade MALT lymphoma of the stomach: a review of treatment options.  Int J Radiat Oncol Biol Phys. 2000;  46 1093-1103
• 253 Schechter N R, Portlock C S, Yahalom J. Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach with radiation alone.  J Clin Oncol. 1998;  16 1916-1921
• 254 Tsang R W, Gospodarowicz M K, Pintilie M. et al . Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome.  J Clin Oncol. 2003;  21 4157-4164
• 255 Tsang R W, Gospodarowicz M K. Radiation therapy for localized low-grade non-Hodgkin’s lymphomas.  Hematol Oncol. 2005;  23 10-17
• 256 Mittal B, Wasserman T H, Griffith R C. Non-Hodgkin’s lymphoma of the stomach.  Am J Gastroenterol. 1983;  78 780-787
• 257 Ettinger D S, Carter D. Gastric carcinoma 16 years after gastric lymphoma irradiation.  Am J Gastroenterol. 1977;  68 485-488
• 258 Shani A, Schutt A J, Weiland L H. Primary gastric malignant lymphoma followed by gastric adenocarcinoma: report of 4 cases and review of the literature.  Cancer. 1978;  42 2039-2044
• 259 Bartlett D L, Karpeh M S, Filippa D A. et al . Long-term follow-up after curative surgery for early gastric lymphoma.  Ann Surg. 1996;  223 53-62
• 260 Kodera Jr Y, Yamamura Y, Nakamura S. et al . The role of radical gastrectomy with systematic lymphadenectomy for the diagnosis and treatment of primary gastric lymphoma.  Ann Surg. 1998;  227 45-50
• 261 Brands F, Monig S P, Raab M. Treatment and prognosis of gastric lymphoma.  Eur J Surg. 1997;  163 803-813
• 262 Aviles A, Nambo M J, Neri N. et al . The role of surgery in primary gastric lymphoma: results of a controlled clinical trial.  Ann Surg. 2004;  240 44-50
• 263 Aviles A, Nambo M J, Neri N. et al . Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: results of a controlled clinical trial.  Med Oncol. 2005;  22 57-62
• 264 ammel P, Haioun C, Chaumette M T. et al . Efficacy of single-agent chemotherapy in low-grade B-cell mucosa-associated lymphoid tissue lymphoma with prominent gastric expression.  J Clin Oncol. 1995;  13 2524-2529
• 265 Nakamura S, Matsumoto T, Suekane H. et al . Long-term clinical outcome of Helicobacter pylori eradication for gastric mucosa-associated lymphoid tissue lymphoma with a reference to second-line treatment.  Cancer. 2005;  104 532-540
• 266 Levy M, Copie-Bergman C, Gameiro C. et al . Prognostic value of translocation t(11;18) in tumoral response of low-grade gastric lymphoma of mucosa-associated lymphoid tissue type to oral chemotherapy.  J Clin Oncol. 2005;  23 5061-5066
• 267 Jäger G, Neumeister P, Brezinschek R. et al . Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study.  J Clin Oncol. 2002;  20 3872-3877
• 268 Streubel B, Ye H, Du M Q. et al . Translocation t(11;18)(q21;q21) is not predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphoma.  Oncology. 2004;  66 476-480
• 269 Raderer M, Wohrer S, Bartsch R. et al . Phase II study of oxaliplatin for treatment of patients with mucosa-associated lymphoid tissue lymphoma.  J Clin Oncol. 2005;  23 8442-8446
• 270 Conconi A, Martinelli G, Thieblemont C. et al . Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type.  Blood. 2003;  102 2741-2745
• 271 Raderer M, Jager G, Brugger S. et al . Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma.  Oncology. 2003;  65 306-310
• 272 Martinelli G, Laszlo D, Ferreri A J. et al . Clinical activity of rituximab in gastric marginal zone non-Hodgkin’s lymphoma resistant to or not eligible for anti-Helicobacter pylori therapy.  J Clin Oncol. 2005;  23 1979-1983
• 273 Chaudhary N, Ozer H, Huard D. et al . Successful treatment of Helicobacter pylori-negative gastric MALT lymphoma with rituximab.  Dig Dis Sci. 2006;  51 775-778
• 274 Salar A, Bellosillo B, Serrano S. et al . Persistent residual disease in t(11;18)(q21;q21) positive gastric mucosa-associated lymphoid tissue lymphoma treated with chemotherapy or rituximab.  J Clin Oncol. 2005;  23 7361-7362
• 275 Ferreri A J, Freschi M, Dell’Oro S. et al . Prognostic significance of the histopathologic recognition of low- and high-grade components in stage I–II B-cell gastric lymphomas.  Am J Surg Pathol. 2001;  25 95-102
• 276 Ferreri A J, Montalban C. Primary diffuse large B-cell lymphoma of the stomach.  Crit Rev Oncol Hematol. 2007;  63 65-71
• 277 Coiffier B, Haioun C, Ketterer N. et al . Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study.  Blood. 1998;  92 1927-1932
• 278 Coiffier B, Lepage E, Briere J. et al . CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.  N Engl J Med. 2002;  346 235-242
• 279 Watanabe T, Tada M, Nagai H. et al . Helicobacter pylori infection induces gastric cancer in mongolian gerbils.  Gastroenterology. 1998;  115 642-648
• 280 Ekström A M, Hansson L E, Signorello L B. et al . Decreasing incidence of both major histologic subtypes of gastric adenocarcinoma – a population-based study in Sweden.  Br J Cancer. 2000;  83 391-396
• 281 WHO/IARC. Infection with Helicobacter pylori.  IARC Monogr Eval Carcinog Risks Hum. 1994;  61 177-240
• 282 Stoicov C, Saffari R, Cai X. et al . Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling.  Gene. 2004;  341 1-17
• 283 Ekström A M, Eriksson M, Hansson L E. et al . Occupational exposures and risk of gastric cancer in a population-based case-control study.  Cancer Res. 1999;  59 5932-5937
• 284 Miehlke S, Kirsch C, Agha-Amiri K. et al . The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany.  Int J Cancer. 2000;  87 322-327
• 285 Ekström A M, Serafini M, Nyrén O. et al . Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden.  Int J Cancer. 2000;  87 133-140
• 286 González C A, Jakszyn P, Pera G. et al . Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).  J Natl Cancer Inst. 2006;  98 345-354
• 287 Sung J J, Lin S R, Ching J Y. et al . Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study.  Gastroenterology. 2000;  119 7-14
• 288 De Jonge P J, Wolters L M, Steyerberg E W. et al . Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Durch cohort.  Aliment Pharmacol Ther. 2007;  26 (1) 31-39
• 289 Tajima Y, Yamazaki K, Makino R. et al . Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.  Br J Cancer. 2007;  96 (1) 631-638
• 290 Crew K D, Neugut A I. Epidemiology of gastric cancer.  World J Gastroenterol. 2006;  12 (3) 354-362
• 291 Meining A, Stolte M. Close correlation of intestinal metaplasia and corpus gastritis in patients infected with Helicobacter pylori.  Z Gastroenterol. 2002;  40 557-560
• 292 Matsuhisa T, Matsukura N, Yamada N. Topography of chronic active gastritis in Helicobacter pylori-positive Asian populations: age-, gender-, and endoscopic diagnosis-matched study.  J Gastroenterol. 2004;  39 324-328
• 293 Imagawa S, Yoshihara M, Ito M. et al . Evaluation of Gastric Cancer Risk Using Topography of Histological Gastritis: A Large-scaled Cross-sectional Study.  Dig Dis Sci. 2007;  13 Epub ahead of print
• 294 Miehlke S, Hackelsberger A, Meining A. et al . Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori.  Br J Cancer. 1998;  78 263-266
• 295 Meining A G, Bayerdörffer E, Stolte M. Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients.  Eur J Gastroenterol Hepatol. 1999;  11 717-720
• 296 Meining A, Riedl B, Stolte M. Features of gastritis predisposing to gastric adenoma and early gastric cancer.  J Clin Pathol. 2002;  55 770-773
• 297 Oberhuber G, Stolte M. Gastric polyps: an update of their pathology and biological significance.  Virchows Arch. 2000;  437 581-590
• 298 Malfertheiner P, Megraud F, O’Morain C. et al . Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.  Gut. 2007;  56 772-781
• 299 Wong B C, Lam S K, Wong W M. et al . : Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.  JAMA. 2004;  291 187-194
• 300 Forman D, Graham D Y. Review article: impact of Helicobacter pylori on society-role for a strategy of ‘search and eradicate’.  Aliment Pharmacol Ther. 2004;  19 (Suppl 1) 17-21
• 301 Fischbach L, Evans E L. Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori.  Aliment Pharmacol Ther. 2007;  26 343-357
• 302 Janssen M J, Laheij R J. et al . The influence of pretreatment on cure rates of Helicobacter pylori eradication.  Neth J Med. 2004;  62 192-196
• 303 Laheij R J, Rossum L G. et al . Evaluation of treatment regimens to cure Helicobacter pylori infection – a meta-analysis.  Aliment Pharmacol Ther. 1999;  13 (7) 857-864
• 304 Megraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing.  Gut. 2004;  53 1374-1384
• 305 Wouden E J, Thijs J C. et al . The influence of in vitro nitroimidazole resistance on the efficacy of nitroimidazole-containing anti-Helicobacter pylori regimens: a meta-analysis.  Am J Gastroenterol. 1999;  94 1751-1759
• 306 Fuccio van der L, Minardi M E. et al . Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication.  Ann Intern Med. 2007;  147 553-562
• 307 Furuta T, Shirai N. et al . Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies.  Drug Metab Pharmacokinet. 2005;  20 153-167
• 308 Gisbert J P, Khorrami S. et al . Meta-analysis: Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer.  Aliment Pharmacol Ther. 2004;  19 617-629
• 309 Graham D Y. Therapy of Helicobacter pylori: current status and issues.  Gastroenterology. 2000;  118 (Suppl 1) S2-S8
• 310 Huang J Q, Zheng G F. et al . Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylori eradication treatments from those with peptic ulcer disease? A systematic review.  World J Gastroenterol. 2005;  11 2726-2732
• 311 Klotz U, Schwab M. et al . CYP2C19 polymorphism and proton pump inhibitors.  Basic Clin Pharmacol Toxicol. 2004;  95 2-8
• 312 Lind T, Megraud F. et al . The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies.  Gastroenterology. 1999;  116 248-253
• 313 Malfertheiner P, Bayerdorffer E. et al . The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer.  Aliment Pharmacol Ther. 1999;  13 703-712
• 314 Malfertheiner P, Peitz U. et al . What constitutes failure for Helicobacter pylori eradication therapy?.  Can J Gastroenterol. 2003;  17 (Suppl B) 53B-57B
• 315 Malfertheiner P, Megraud F. et al . Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.  Gut. 2007;  56 772-781
• 316 Moayyedi P, Soo S. et al . Eradication of Helicobacter pylori for non-ulcer dyspepsia.  Cochrane Database Syst Rev. 2006;  2 CD002096
• 317 Morgner A, Labenz J. et al . Effective regimens for the treatment of Helicobacter pylori infection.  Expert Opin Investig Drugs. 2006;  15 995-1016
• 318 Padol S, Yuan Y. et al . The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta-analysis.  Am J Gastroenterol. 2006;  101 1467-1475
• 319 Treiber G, Malfertheiner P. et al . Treatment and dosing of Helicobacter pylori infection: when pharmacology meets clinic.  Expert Opin Pharmacother. 2007;  8 329-350
• 320 Vakil N, Megraud F. Eradication therapy for Helicobacter pylori.  Gastroenterology. 2007;  133 985-1001
• 321 Hopkins R J. Current FDA-approved treatments for Helicobacter pylori and the FDA approval process.  Gastroenterology. 1997;  113 S126-S130
• 322 Graham D Y, Lu H. et al . A report card to grade Helicobacter pylori therapy.  Helicobacter. 2007;  12 275-278
• 323 Calvet X, Garcia N. et al . A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection.  Aliment Pharmacol Ther. 2000;  14 603-609
• 324 Chiba N, Rao B V. et al . Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori.  Am J Gastroenterol. 1992;  87 1716-1727
• 325 Gisbert J P, Khorrami S. et al . Meta-analysis: proton pump inhibitors vs. H 2-receptor antagonists – their efficacy with antibiotics in Helicobacter pylori eradication.  Aliment Pharmacol Ther. 2003;  18 757-766
• 326 Graham D Y, Hammoud F. et al . Meta-analysis: proton pump inhibitor or H 2-receptor antagonist for Helicobacter pylori eradication.  Aliment Pharmacol Ther. 2003;  17 1229-1236
• 327 Huang J, Hunt R H. The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole.  Aliment Pharmacol Ther. 1999;  13 719-729
• 328 Treiber G. The influence of drug dosage on Helicobacter pylori eradication: a cost-effectiveness analysis.  Am J Gastroenterol. 1996;  91 246-257
• 329 Treiber G. Treating H. pylori shorter than one week – a real future perspective?.  Z Gastroenterol. 2000;  38 807-812
• 330 Unge P. Antimicrobial treatment of H. pylori infection – a pooled efficacy analysis of eradication therapies.  Eur J Surg Suppl. 1998;  582 16-26
• 331 Ford A C, Delaney B C. et al . Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis.  Am J Gastroenterol. 2004;  99 1833-1855
• 332 Gene E, Calvet X. et al . Triple vs. quadruple therapy for treating Helicobacter pylori infection: a meta-analysis.  Aliment Pharmacol Ther. 2003;  17 1137-1143
• 333 Kist M. Helicobacter pylori: primary antimicrobial resistance and first-line treatment strategies.  Euro Surveill. 2007;  12 E1-E2
• 334 Taylor J L, Zagari M. et al . Pharmacoeconomic comparison of treatments for the eradication of Helicobacter pylori.  Arch Intern Med. 1997;  157 87-97
• 335 Wolle K, Leodolter A. et al . Antibiotic susceptibility of Helicobacter pylori in Germany: stable primary resistance from 1995 to 2000.  J Med Microbiol. 2002;  51 705-709
• 336 Fischbach L A, Zanten van S. et al . Meta-analysis: the efficacy, adverse events, and adherence related to first-line anti-Helicobacter pylori quadruple therapies.  Aliment Pharmacol Ther. 2004;  20 1071-1082
• 337 Neville P M, Everett S. et al . The optimal antibiotic combination in a 5-day Helicobacter pylori eradication regimen.  Aliment Pharmacol Ther. 1999;  13 497-501
• 338 Treiber G, Wittig J. et al . Clinical outcome and influencing factors of a new short-term quadruple therapy for Helicobacter pylori eradication: a randomized controlled trial (MACLOR study).  Arch Intern Med. 2002;  162 153-160
• 339 Vaira D, Zullo A. et al . Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial.  Ann Intern Med. 2007;  146 556-563
• 340 Zullo A, De Francesco V. et al . The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis.  Gut. 2007;  56 1353-1357
• 341 Treiber G, Malfertheiner P. et al . Treatment and dosing of Helicobacter pylori infection: when pharmacology meets clinic.  Expert Opin Pharmacother. 2007;  8 329-350
• 342 Janssen M J, Laheij R J. et al . Meta-analysis: the influence of pre-treatment with a proton pump inhibitor on Helicobacter pylori eradication.  Aliment Pharmacol Ther. 2005;  21 341-345
• 343 Klotz U, Schwab M. et al . CYP2C19 polymorphism and proton pump inhibitors.  Basic Clin Pharmacol Toxicol. 2004;  95 2-8
• 344 Bortoli de N, Leonardi G. et al . Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics.  Am J Gastroenterol. 2007;  102 951-956
• 345 Gotteland M, Brunser O. et al . Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?.  Aliment Pharmacol Ther. 2006;  23 1077-1086
• 346 Tong J L, Ran Z H. et al . Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy.  Aliment Pharmacol Ther. 2007;  25 55-68
• 347 Leodolter A, Kulig M. et al . A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer.  Aliment Pharmacol Ther. 2001;  15 1949-1958
• 348 Treiber G, Lambert J R. The impact of Helicobacter pylori eradication on peptic ulcer healing.  Am J Gastroenterol. 1998;  93 1080-1084
• 349 Adamek R J, Opferkuch W. et al . Cure of Helicobacter pylori infection: role of duration of treatment with omeprazole and amoxicillin.  Am J Gastroenterol. 1996;  91 98-100
• 350 Wouden E J, Thijs J C. et al . The influence of in vitro nitroimidazole resistance on the efficacy of nitroimidazole-containing anti-Helicobacter pylori regimens: a meta-analysis.  Am J Gastroenterol. 1999;  94 1751-1759
• 351 Gisbert J P, Pajares J M. Helicobacter pylori „rescue” therapy after failure of two eradication treatments.  Helicobacter. 2005;  10 363-372
• 352 Gisbert J P, Morena van der F. Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure.  Aliment Pharmacol Ther. 2006;  23 35-44
• 353 Miehlke S, Schneider-Brachert W, Kirsch C. et al . One-week once-daily triple therapy with esomeprazole, moxifloxacin, and rifabutin for eradication of persistent Helicobacter pylori resistant to both metronidazole and clarithromycin.  Helicobacter. 2008;  13 69-74
• 354 Yuan Y, Thabane L. et al . Levofloxacin-based rescue regimens after Helicobacter pylori treatment failure: how strong is the evidence?.  Aliment Pharmacol Ther. 2006;  23 1283-1285; author reply 1285 – 1286
• 355 Koletzko S, Feydt-Schmidt A. Infants differ from teenagers: use of non-invasive tests for detection of Helicobacter pylori infection in children.  Eur J Gastroenterol Hepatol. 2001;  13 1047-1052
• 356 Jones N, Fallone C, Flook N. et al . Consensus Conference: Update on the Management of Helicobacter pylori – An evidence-based evaluation of Helicobacter pylori infection and clinical sequelae in children and adolescents.  Can J Gastroenterol. 2005;  19 398-408
• 357 Drumm B, Koletzko S, Oderda G. Helicobacter pylori infection in children: A consensus statement.  J Pediatr Gastroenterol Nutr. 2000;  30 207-213
• 358 Koletzko S, Richy F, Bontems P. et al . Prospective multicenter study on antibiotic resistance of Helicbacter pylori strains obtained from children living in Europe.  Gut. 2006;  55 1711-1716
• 359 Kurugoglu S, Mihmanli I, Celkan T. et al . Radiological features in paediatric primary gastric MALT lymphoma and association with Helicobacter pylori.  Pediatr Radiol. 2002;  32 82-87
• 360 Lionetti E, Miniello V L, Castellaneta S P. et al . Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial.  Aliment Pharmacol Ther. 2006;  24 1461-1468
• 361 Khurana R, Fischbach L, Chiba N. et al . Meta-analysis: Helicobacter pylori eradication treatment efficacy in children.  Aliment Pharmacol Ther. 2007;  25 523-536
• 362 Oderda G, Shcherbakov P, Bontems P. et al . Results from the pediatric European register for treatment of Helicobacter pylori (PERTH).  Helicobacter. 2007;  12 150-156
• 363 Feydt-Schmidt A, Kindermann A, Konstantopoulos N. et al . Reinfection rate in children after successful Helicobacter pylori eradication.  Eur J Gastroenterol Hepatol. 2002;  14 1119-1123
• 364 Rowland M, Kumar D, Daly L. et al . Low rates of Helicobacter pylori reinfection in children.  Gastroenterology. 1999;  117 336-341
• 365 Rasquin A, Di Lorenzo C, Forbes D. et al . Childhood functional gastrointestinal disorders: child/adolescent.  Gastroenterology. 2006;  130 1527-1537
• 366 Kohli R, Li B UK. Differential diagnosis of recurrent abdominal pain: new considerations.  Pediatric Annals. 2004;  33 113-122
• 367 Chitkara D K, Rawat D J, Talley N J. The epidemiology of childhood recurrent abdominal pain in Western countries: a systematic review.  Am J Gastroenterol. 2005;  100 1868-1875
• 368 Hyams J S, Burke G, Davis P M. et al . Abdominal pain and irritable bowel syndrome in adolescents: a community-based study.  J Pediatr. 1996;  129 220-226
• 369 Apley J, Naish N. Recurrent abdominal pains: A field survey of 1,000 school children.  Arch Dis Child. 1958;  33 165-170
• 370 Tindberg Y, Nyren O, Blennow M. et al . Helicobacter pylori infection and abdominal symptoms among Swedish school children.  J Pediatr Gastroenterol Nutr. 2005;  41 33-38
• 371 Falsafi T, Valizadeh N, Sepehr S. et al . Application of a stool antigen test to evaluate the incidence of Helicobacter pylori infection in children and adolescents from Tehran, Iran.  Clin Diagn Lab Immunol. 2005;  12 1094-1097
• 372 Leandro Liberato S V, Hernandez Galindo M, Torroba Alvarez L. et al . Helicobacter pylori infection in the child population in Spain: prevalence, related factors and influence on growth.  Ann Pediatr. 2005;  63 489-494
• 373 Bode G, Brenner H, Adler G. et al . Recurrent abdominal pain in children: evidence from a population-based study that social and familial factors play a major role but not Helicobacter pylori infection.  J Psychosom Res. 2003;  54 417-421
• 374 Bode G, Rothenbacher D, Brenner H. et al . Helicobacter pylori and abdominal symptoms: a population-based study among preschool children in southern Germany.  Pediatrics. 1998;  101 634-637
• 375 Macarthur C, Saunders N, Feldman W. Helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in children.  JAMA. 1995;  273 729-734
• 376 Macarthur C, Saunders N, Feldman W. et al . Helicobacter pylori and childhood recurrent abdominal pain: community based case-control study.  BMJ. 1999;  319 822-823
• 377 Kalach N, Mention K, Guimber D. et al . Helicobacter pylori infection is not associated with specific symptoms in nonulcer-dyspeptic children.  Pediatrics. 2005;  115 17-21
• 378 Das B K, Kakkar S, Dixit V K. et al . Helicobacter pylori infection and recurrent abdominal pain in children.  J Trop Pediatr. 2003;  49 250-252
• 379 Frank F, Stricker T, Stallmach T. et al . Helicobacter pylori infection in recurrent abdominal pain.  J Pediatr Gastroenterol Nutr. 2000;  31 424-427
• 380 Wewer V, Andersen L P, Paerregaard A. et al . Treatment of Helicobacter pylori in children with recurrent abdominal pain.  Helicobacter. 2001;  6 244-248
• 381 Alfven G. One hundred cases of recurrent abdominal pain in children: diagnostic procedures and criteria for a psychosomatic diagnosis.  Acta Paediatr. 2003;  92 43-49
• 382 Ukarapol N, Lertprasertsuk N, Wongsawasdi L. Recurrent abdominal pain in children: the utility of upper endoscopy and histopathology.  Singapore Med J. 2004;  45 121-124
• 383 Ashorn M, Rago T, Kokkonen J. et al . Symptomatic response to Helicobacter pylori eradication in children with recurrent abdominal pain: double blind randomized placebo-controlled trial.  J Clin Gastroenterol. 2004;  38 646-650
• 384 Rafeey M, Jafari-Rouhi A H, Gassemi B A. et al . Relationship between endoscopic nodular gastritis and Helicobacter pylori infection in children.  Indian J Gastroenterol. 2004;  23 138-139
• 385 Bahu M G, da Silveira T R, Maguilnick I. et al . Endoscopic nodular gastritis: an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori.  J Pediatr Gastroenterol Nutr. 2003;  36 217-222
• 386 Luzza F, Pensabene L, Imeneo M. et al . Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection.  Helicobacter. 2002;  7 46-52
• 387 Ganga Z P, Michaud L, Vincent P. et al . Natural outcome of Helicobacter pylori infection in asymptomatic children: a two-year follow-up study.  Pediatrics. 1999;  104 216-221
• 388 Barabino A, Dufour C, Marino C E. et al . Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: Further clinical evidence.  J Pediatr Gastroenterol Nutr. 1999;  28 (1) 116-119
• 389 Ashorn M, Ruuska T, Makipernaa A. Helicobacter pylori and iron deficiency anaemia in children.  Scand J Gastroenterol. 2001;  36 701-705
• 390 Choe Y H, Lee J E, Kim S K. Effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection.  Acta Paediatr. 2000;  89 154-157
• 391 Choe Y H, Kim S K, Son B K. et al . Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents.  Helicobacter. 1999;  4 135-139
• 392 Emin-Kurekci A, Avni-Atay A, Umit-Sarici S. et al . Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia?.  J Trop Pediatr. 2005;  51 166-169
• 393 Gessner B D, Baggett H C, Muth P T. et al . A controlled, household-randomized, open-label trial of the effect that treatment of Helicobacter pylori infection has on iron deficiency in children in rural Alaska.  J Infect Dis. 2006;  193 537-546
• 394 Kerr J G, Al-Khattaf A, Barson A J. et al . An association between sudden infant death syndrome (SIDS) and Helicobacter pylori infection.  Arch Dis Child. 2000;  83 429-434
• 395 Karlidag T, Bulut Y, Keles E. et al . Detection of Helicobacter pylori in children with otitis media with effusion: a preliminary report.  Laryngoscope. 2005;  115 1262-1265
• 396 Koletzko S, Konstantopoulos N, Lehn N. et al . Control your controls and conclusions.  Arch Dis Child. 2001;  84 525
• 397 Bitar M, Mahfouz R, Soweid A. et al . Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease?.  Acta Otolaryngol. 2006;  126 154-159
• 398 Vaira D, Menegatti M, Salardi S. et al . Helicobacter pylori and diminished growth in children: is it simply a marker of deprivation?.  Ital J Gastroenterol Hepatol. 1998;  30 129-133
• 399 Richter T, Richter T, List S. et al . Five- to 7-year-old children with Helicobacter pylori infection are smaller than Helicobacter-negative children: a cross-sectional population-based study of 3,315 children.  J Pediatr Gastroenterol Nutr. 2001;  33 472-475
• 400 Oderda G, Palli D, Saieva C. et al . Short stature and Helicobacter pylori infection in italian children: prospective multicentre hospital based case-control study. The Italian Study Group on Short Stature and H pylori.  BMJ. 1998;  317 514-515
• 401 Pitkaranta A, Kolho K L, Rautelin H. Helicobacter pylori in children who are prone to upper respiratory tract infections.  Arch Otolaryngol Head Neck Surg. 2005;  131 256-258
• 402 Kindermann A, Demmelmair H, Koletzko B. et al . Influence of age on 13C-urea breath test results in children.  J Pediatr Gastroenterol Nutr. 2000;  30 85-91
• 403 Cadranel S, Corvaglia L, Bontems P. et al . Detection of Helicobacter pylori infection in children with standardized and simplified 13C-urea breath test.  J Pediatr Gastroenterol Nutr. 1998;  27 275-280
• 404 Megraud F. Comparison of non-invasive tests to detect Helicobacter pylori infection in children and adolescents: results of a multicenter European study.  J Pediatr. 2005;  146 198-203
• 405 Kato S, Ozawa K, Konno M. et al . Diagnostic accuracy of the 13C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study.  Am J Gastroenterol. 2002;  97 1668-1673
• 406 Herold R, Becker M. 13C-urea breath test threshold calculation and evaluation for the detection of Helicobacter pylori infection in children.  BMC Gastroenterol. 2002;  2 12
• 407 Koletzko S. Noninvasive diagnostic tests for Helicobacter pylori infection in children.  Can J Gastroenterol. 2005;  19 433-439
• 408 Imrie C, Rowland M, Bourke B. et al . Limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants.  J Pediatr. 2001;  139 734-737
• 409 Klein P D, Malaty H M, Czinn S J. et al . Normalizing results of 13C-urea breath testing for CO 2 production rates in children.  J Pediatr Gastroenterol Nutr. 1999;  29 297-301
• 410 Graham D Y, Opekun A R, Jogi M. et al . False negative urea breath tests with H 2-receptor antagonists: interactions between Helicobacter pylori density and pH.  Helicobacter. 2004;  9 17-27
• 411 Graham D Y, Opekun A R, Hammoud F. et al . Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors.  Am J Gastroenterol. 2003;  98 1005-1009
• 412 Megraud F. Non-invasive tests to detect Helicobacter pylori infection in children and adolescents: results of a multicentric European study.  J Pediatr. 2005;  146 198-203
• 413 Koletzko S, Konstantopoulos N, Bosman D. et al . Evaluation of a novel monoclonal enzyme immunoassay for detection of Helicobacter pylori antigen in stool from children.  Gut. 2003;  52 804-806
• 414 Schwarzer A, Lottspeich C, Russmann H. et al . Evaluation of a novel rapid one-step monoclonal chromatographic immunoassay for detection of Helicobacter pylori in stool from children.  Eur J Clin Microbiol Infect Dis. 2007;  26 475-480
• 415 Hino B, Eliakim R, Levine A. et al . Comparison of invasive and non-invasive tests diagnosis and monitoring of Helicobacter pylori infection in children.  J Pediatr Gastroenterol Nutr. 2004;  39 519-523
• 416 Gisbert J P, Morena de la F, Abraira V. Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis.  Am J Gastroenterol. 2006;  101 1921-1930
• 417 Konstantopoulos N, Russmann H, Tasch C. et al . Evaluation of the Helicobacter pylori stool antigen test (HpSA) for detection of Helicobacter pylori infection in children.  Am J Gastroenterol. 2001;  96 677-683
• 418 Makristathis A, Barousch W, Pasching E. et al . Two enzyme immunoassays and PCR for detection of Helicobacter pylori in stool specimens from Pediatric Patients before and after eradication therapy.  J Clin Microbiol. 2000;  38 3710-3714
• 419 Antos D, Crone J, Konstantopoulos N. et al . Evaluation of a novel rapid one-step immunochromatographic assay for detection of monoclonal Helicobacter pylori antigen in stool samples from children.  J Clin Microbiol. 2005;  43 2598-2601
• 420 Lottspeich C, Schwarzer A, Panthel K. et al . Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens from symptomatic children.  J Clin Microbiol. 2007;  45 1718-1722
• 421 Oliveira A MR, Rocha G A, Queiroz D M. et al . Evaluation of enzyme-linked immunosorbent assay for the diagnosis of Helicobacter pylori infection in children from different age groups with and without duodenal ulcer (see comments).  J Pediatr Gastroenterol Nutr. 1999;  28 157-161
• 422 Kindermann A, Konstantopoulos N, Lehn N. et al . Evaluation of two commercial enzyme immunoassays, testing immunoglobulin G (IgG) and IgA responses, for diagnosis of Helicobacter pylori infection in children.  J Clin Microbiol. 2001;  39 3591-3596
• 423 Rocha G A, Oliveira A M, Queiroz D M. et al . Immunoblot analysis of humoral immune response to Helicobacter pylori in children with and without duodenal ulcer.  J Clin Microbiol. 2000;  38 1777-1781
• 424 Ni Y H, Lin J T, Huang S F. et al . Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6 other currently available tests in children (see comments).  J Pediatr. 2000;  136 823-827
• 425 Raymond J, Sauvestre C, Kalach N. et al . Immunoblotting and serology for diagnosis of Helicobacter pylori infection in children.  Pediatr Infect Dis J. 2000;  19 118-121
• 426 Raymond J, Sauvestre C, Kalach N. et al . Evaluation of a new serologic test for diagnosis of Helicobacter pylori infection in children.  Eur J Clin Microbiol Infect Dis. 1999;  18 192-198
• 427 Kalach N, Benhamou P H, Campeotto F. et al . Clarithromycin resistance and eradication of Helicobacter pylori in children.  Antimicrob Agents Chemother. 2001;  45 2134-2135
• 428 Wolle K, Leodolter A, Malfertheiner P. et al . Antibiotic susceptibility of Helicobacter pylori in Germany: stable primary resistance from 1995 to 2000.  J Med Microbiol. 2002;  51 705-709
• 429 Pohle T, Stoll R, Kirchner T. et al . Eradication of Helicobacter pylori with lansoprazole, roxithromycin and metronidazole – an open pilot study.  Aliment Pharmacol Ther. 1998;  12 1273-1278
• 430 Megraud F, Lehn N, Lind T. et al . Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study.  Antimicrob Agents Chemother. 1999;  43 2747-2752
• 431 Arenz T, Antos D, Russmann H. et al . Esomeprazole-based 1-week triple therapy directed by susceptibility testing for eradication of Helicobacter pylori infection in children.  J Pediatr Gastroenterol Nutr. 2006;  43 180-184
• 432 Feydt-Schmidt A, Russmann H, Lehn N. et al . Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin-susceptible and clarithromycin-resistant Helicobacter pylori strains in gastric biopsies from children.  Aliment Pharmacol Ther. 2002;  16 2073-2079
• 433 Rüssmann H, Feydt-Schmidt A, Adler K. et al . Detection of Helicobacter pylori in paraffin-embedded and in shock-frozen gastric biopsy samples by fluorescent in situ hybridization.  J Clin Microbiol. 2003;  41 813-815
• 434 Drumm B, Rhoads J M, Stringer D A. et al . Peptic ulcer disease in children: etiology, clinical findings, and clinical course.  Pediatrics. 1988;  82 410-414
• 435 Kivi M, Tindberg Y, Sorberg M. et al . Concordance of Helicobacter pylori strains within families.  J Clin Microbiol. 2003;  41 5604-5608
• 436 Crone J, Granditsch G, Huber W D. et al . Helicobacter pylori in children and adolescents: increase of primary clarithromycin resistance, 1997 – 2000.  J Pediatr Gastroenterol Nutr. 2003;  36 368-371
• 437 Francavilla R, Lionetti E, Castellaneta S P. et al . Improved efficacy of 10-Day sequential treatment for Helicobacter pylori eradication in children: a randomized trial.  Gastroenterology. 2005;  129 1414-1419
• 438 Zullo A, Francesco, V. et al . The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis.  Gut. 2007;  56 1353-1357
• 439 Miehlke S, Kirsch C, Schneider-Brachert W. et al . A prospective, randomized study of quadruple therapy and high-dose dual therapy for treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin.  Helicobacter. 2003;  8 310-319
• 440 Gatta L, Vakil N, Ricci C. et al . Effect of proton pump inhibitors and antacid therapy on 13C urea breath tests and stool test for Helicobacter pylori infection.  Am J Gastroenterol. 2004;  99 823-829
• 441 Miehlke S, Bayerdorffer E, Lehn N. et al . Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection.  Eur J Gastroenterol Hepatol. 1995;  7 975-978
• 442 Kalach N, Bergeret M, Benhamou P H. et al . High levels of resistance to metronidazole and clarithromycin in Helicobacter pylori strains in children.  J Clin Microbiol. 2001;  39 394-397
• 443 Hansen J M, Hallas J, Lauritsen J M. et al . Non-steroidal anti-inflammatory drugs and ulcer complications: a risk factor analysis for clinical decision-making.  Scand J Gastroenterol. 1996;  31 126-130
• 444 Hernandez-Diaz S, Rodriguez L A. Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990 s.  Arch Intern Med. 2000;  160 2093-2099
• 445 Hawkey C J, Weinstein W M, Smalley W. et al . Effect of Risk Factors on Complicated and Uncomplicated Ulcers in the TARGET Lumiracoxib Outcomes Study.  Gastroenterology. 2007;  133 57-64
• 446 Henry D, Lim L L, Garcia Rodriguez L A. et al . Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis.  BMJ. 1996;  312 1563-1566
• 447 Weil J, Langman M J, Wainwright P. et al . Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs.  Gut. 2000;  46 27-31
• 448 Scheiman J M, Yeomans N D, Talley N J. et al . Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors.  Am J Gastroenterol. 2006;  101 701-710
• 449 Miyake K, Ueki N, Suzuki K. et al . Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine.  Aliment Pharmacol Ther. 2005;  21 (Suppl 2) 67-72
• 450 Stupnicki T, Dietrich K, Gonzalez-Carro P. et al . Efficacy and tolerability of pantoprazole compared with misoprostol for the prevention of NSAID-related gastrointestinal lesions and symptoms in rheumatic patients.  Digestion. 2003;  68 198-208
• 451 Labenz J, Blum A L, Bolten W W. et al . Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients: a randomised, double blind, placebo controlled, clinical trial.  Gut. 2002;  51 329-335
• 452 Graham D Y, Agrawal N M, Campbell D R. et al . Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole.  Arch Intern Med. 2002;  162 169-175
• 453 Silverstein F E, Faich G, Goldstein J L. et al . Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.  JAMA. 2000;  284 1247-1255
• 454 Bombardier C, Laine L, Reicin A. et al . Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.  N Engl J Med. 2000;  343 1520-1528
• 455 Chan F K, Hung L C, Suen B Y. et al . Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis.  N Engl J Med. 2002;  347 2104-2110
• 456 Chan F K, Hung L C, Suen B Y. et al . Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial.  Gastroenterology. 2004;  127 1038-1043
• 457 Hooper L, Brown T J, Elliott R. et al . The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review.  BMJ. 2004;  329 948
• 458 Kearney P M, Baigent C, Godwin J. et al . Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials.  BMJ. 2006;  332 1302-1308
• 459 Rostom A, Muir K, Dube C. et al . Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review.  Clin Gastroenterol Hepatol. 2007;  5 818-828, 828 e811 – 815; quiz 768
• 460 Chan F K, Wong V W, Suen B Y. et al . Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.  Lancet. 2007;  369 1621-1626
• 461 Goldstein J L, Cryer B, Amer F. et al . Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial.  Clin Gastroenterol Hepatol. 2007;  5 1167-1174
• 462 Stack W A, Atherton J C, Hawkey G M. et al . Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding.  Aliment Pharmacol Ther. 2002;  16 497-506
• 463 Chan F K, To K F, Wu J C. et al . Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial.  Lancet. 2002;  359 9-13
• 464 Lai K C, Lau C S, Ip W Y. et al . Effect of treatment of Helicobacter pylori on the prevention of gastroduodenal ulcers in patients receiving long-term NSAIDs: a double-blind, placebo-controlled trial.  Aliment Pharmacol Ther. 2003;  17 799-805
• 465 Vergara M, Catalan M, Gisbert J P. et al . Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users.  Aliment Pharmacol Ther. 2005;  21 1411-1418
• 466 Lai K C, Lam S K, Chu K M. et al . Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti-inflammatory drug users – a randomized trial.  Aliment Pharmacol Ther. 2003;  18 829-836
• 467 Hawkey C J, Tulassay Z, Szczepanski L. et al . Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention.  Lancet. 1998;  352 1016-1021
• 468 Chan F K, Chung S C, Suen B Y. et al . Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.  N Engl J Med. 2001;  344 967-973
• 469 Weil J, Colin-Jones D, Langman M. et al . Prophylactic aspirin and risk of peptic ulcer bleeding.  BMJ. 1995;  310 827-830
• 470 Kelly J P, Kaufman D W, Jurgelon J M. et al . Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product.  Lancet. 1996;  348 1413-1416
• 471 Slattery J, Warlow C P, Shorrock C J. et al . Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin – analysis of gastrointestinal bleeding during the UK-TIA trial.  Gut. 1995;  37 509-511
• 472 Yeomans N D, Lanas A I, Talley N J. et al . Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin.  Aliment Pharmacol Ther. 2005;  22 795-801
• 473 Lanas A, Fuentes J, Benito R. et al . Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin.  Aliment Pharmacol Ther. 2002;  16 779-786
• 474 Lai K C, Lam S K, Chu K M. et al . Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.  N Engl J Med. 2002;  346 2033-2038
• 475 Chan F K, Ching J Y, Hung L C. et al . Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.  N Engl J Med. 2005;  352 238-244
• 476 Lai K C, Chu K M, Hui W M. et al . Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.  Clin Gastroenterol Hepatol. 2006;  4 860-865
• 477 Hallas J, Dall M, Andries A. et al . Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study.  BMJ. 2006;  333 726
• 478 Summers R W, Switz D M, Sessions J T. et al . National Cooperative Crohn’s Disease Study: results of drug treatment.  Gastroenterology. 1979;  77 847-869
• 479 Malchow Jr H, Ewe K, Brandes J W. et al . European Cooperative Crohn’s Disease Study (ECCDS): results of drug treatment.  Gastroenterology. 1984;  86 249-266
• 480 Guslandi M, Tittobello A. Symptomatic response to omeprazole in inflammatory bowel disease.  J Clin Gastroenterol. 1996;  22 159-160
• 481 Dickinson J B. Is omeprazole helpful in inflammatory bowel disease?.  J Clin Gastroenterol. 1994;  18 317-319
• 482 Cheung A N, Ng I O. Cytomegalovirus infection of the gastrointestinal tract in non-AIDS patients.  Am J Gastroenterol. 1993;  88 1882-1886
• 483 Dorigo-Zetsma J W, Meer J T, Tersmette van der M. et al . Value of laboratory investigations in clinical suspicion of cytomegalovirus-induced upper gastrointestinal tract ulcerations in HIV-infected patients.  J Med Virol. 1996;  49 29-33
• 484 Peter A, Telkes G, Varga M. et al . Endoscopic diagnosis of cytomegalovirus infection of upper gastrointestinal tract in solid organ transplant recipients: Hungarian single-center experience.  Clin Transplant. 2004;  18 580-584
• 485 Pruitt B A, Foley F D, Moncrief J A. Curling’s ulcer: a clinical-pathology study of 323 cases.  Ann Surg. 1970;  172 523-539
• 486 Cook D J, Fuller H D, Guyatt G H. et al . Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group.  N Engl J Med. 1994;  330 377-381
• 487 Cook D J, Reeve B K, Guyatt G H. et al . Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses.  Jama. 1996;  275 308-314
• 488 Tryba Jr M, Cook D. Current guidelines on stress ulcer prophylaxis.  Drugs. 1997;  54 581-596
• 489 Rosen H R, Vlahakes G J, Rattner D W. Fulminant peptic ulcer disease in cardiac surgical patients: pathogenesis, prevention, and management.  Crit Care Med. 1992;  20 354-359
• 490 Janicki T, Stewart S. Stress-ulcer prophylaxis for general medical patients: a review of the evidence.  J Hosp Med. 2007;  2 86-92