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TOXIC PRINCIPLES OF HIPPOMANE MANCINELLA
14 January 2009 (online)
The alcoholic extract of the leaves and twigs of Hippomane mancinella L. was separated first into two toxic fractions: the water-soluble (A) and the ether-soluble (B). Chromatography of (A) gave fractions A1–A7, all of which were purified and characterized. A± was found to be 2–hydroxy–4,6–dimethoxyacetophenone. Fraction A5 was shown to be ellagic acid while A 2–A 4 were its tri–, di– and monomethyl ethers respectively. Ae and A7 were found to be the toxic principles of the aqueous (A) fraction and were named hippomanins B and A respectively. Of these, the major component, hippomanin A was obtained as a pale yellow crystalline solid of molecular formula C27H22O18.