CARDIAC PHARMACO–TOXICOLOGICAL STUDIES OF JUDAICIN, ISOLATED FROM ARTEMISIA JUDAICA

E. E. Galal; A. Kandil; M. Abdel Latif; T. Khedr; S. M. Khafagy

doi:10.1055/s-0028-1097918

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Planta Med 1974; 25(1): 88-91
DOI: 10.1055/s-0028-1097918

CARDIAC PHARMACO–TOXICOLOGICAL STUDIES OF JUDAICIN, ISOLATED FROM ARTEMISIA JUDAICA

E. E. Galal, A. Kandil, M. Abdel Latif, T. Khedr, S. M. Khafagy

Drug Research and Control Centre, Cairo, Egypt

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Publication Date:
14 January 2009 (online)

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Abstract

We investigated the digitalis like potentialities of judaicin in rats. Both the pharmacologie and the toxic actions of judaicin and digoxin were studied in respect to. the cardiac response. The pharmacological action as well as the cardiotoxic action of both drugs were electrocardiographically parallel. Both drugs caused a prolongation in the P–R interval and enforcement of the cardiac contractility.

Further investigations are required for completing the picture of the pharmacological action of judaicin.