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Planta Med 1977; 32(5): 27-32
DOI: 10.1055/s-0028-1097554
© Georg Thieme Verlag Stuttgart · New York

CALLUS– UND SUSPENSIONSKULTUREN VON SILYBUM MARIANUM

II. Mitteilung: Umsetzung von Flavonoiden mit Coniferylalkohol zu FlavonolignanenTissue and suspension cultures of Silyhum marianumII. Communication: The formation of flavonolignans by feeding suspension cultures with flavonoids and coniferyl alcoholR. Schrall, H. Becker
  • Institut für Pharmazeutische Biologie der Universität Heidelberg
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Publication Date:
13 January 2009 (online)

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Abstract

By feeding taxifolin and coniferyl alcohol, the formal components of silymarin from the fruits of Silybum marianum, silybin could be isolated out of the substrate of a Silybum suspension culture; silybin was identified by spectroscopic methods. Horseradish-peroxidase and a cell free extract of silybum suspension cultures were also able to synthesize silybin starting from taxifolin and coniferyl alcohol. In an analogue way hydnocarpin, a flavonolignan from Hydnocarpus wightiana, was synthesied by feeding Silybum suspension cultures with luteolin and coniferyl alcohol.