BIOTRANSFORMATION VON CARDENOLIDEN DURCH ZELLSUSPENSIONSKULTUREN VON DIGITALIS LANATA UND THEVETIA NERIIFOLIA1

P. C. Döller; A. W. Alfermann; E. Reinhard

doi:10.1055/s-0028-1097479

Planta Med 1977; 31(1): 1-7
DOI: 10.1055/s-0028-1097479

BIOTRANSFORMATION VON CARDENOLIDEN DURCH ZELLSUSPENSIONSKULTUREN VON DIGITALIS LANATA UND THEVETIA NERIIFOLIA¹

Biotransformation of Cardenolides by Cell Suspension Cultures of Digitalis lanata and Thevetia neriifoliaP. C. Döller, A. W. Alfermann, E. Reinhard

Lehrstuhl für Pharmazeutische Biologie der Universität Tübingen

1 Mit Unterstützung des Bundesministeriurns für Forschung und Technologie.

Abstract

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Abstract

Cell cultures of Digitalis lanata and of Thevetia neriifolia were incubated with different cardenolides. Cymarin was glucosylated to k-strophanthin by Thevetia cell cultures, peruvosid to a diglycoside. Administered thevetin A and B, respectively, were deglucosylated to peruvosid and neriifolin. Lanatoside A was desacetylated and deglucosylated to digitoxin. Cell cultures of Digitalis glucosylated peruvosid to the diglycoside and deglucosylated thevetin A and B. Thevetia as well as Digitalis cell cultures were able to reduce C–19 of peruvosid to neriifolin.

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