Abstract
Chronic administration of Momordica charantia L. fruit extract (1.75 g/day oral for 60 days) caused testicular lesions resulting
in a mass atrophy of the spermatogenic elements. 75 + 8.9 % of the seminiferous tubules
completely lacked step 1–8 spermatid. M. charantia fruit extract administration reduced the contents of RNA, protein, sialic acid and
acid–phosphatase enzyme activity of the testes, whereas the cholesterol contents of
the testes were elevated. Serum enzymes (SGPT, alkaline, acid phosphatase), serum
protein, cholesterol, bilirubin, phospholipids, triglycérides, free cholesterol, creatine
phosphate, blood sugar, blood urea levels were in normal range. Non esterified fatty
acid levels were elevated. Hematological studies did not reveal any deviation from
the normal range except a slight rise in total leucocyte count. In conclusion M. charantia fruit extract administration induced an infertility state without altering general
metabolic activities.
Key Word Index
Momordica charantia - Testicular function
