The Effects of Saikosaponins on Biological Membranes

Hiroko Abe; Machiko Sakaguchi; Hiroyoshi Konishi; Tadato Tani; Shigeru Arichi

doi:10.1055/s-0028-1097428

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Planta Med 1978; 34(6): 160-166
DOI: 10.1055/s-0028-1097428

Research Articles

The Effects of Saikosaponins on Biological Membranes

1. The Relationship between the Structures of Saikosaponins and Haemolytic ActivityHiroko Abe, Machiko Sakaguchi, Hiroyoshi Konishi, Tadato Tani, Shigeru Arichi

The Research Institute of Oriental Medicine, Kinki Universfty School of Medicine, Osaka, Japan.

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Publikationsdatum:
13. Januar 2009 (online)

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Abstract

The relationship between haemolytic activity and the structure of saikosaponins which were isolated from the root of Bupleurum falcatum L. was investigated. It was confirmed that the bridged 13β, 28–epoxyoleanene system in saikosaponin is important to haemolytic activity and that the axial C₁₆β–OH and C₂₃–OH group are also significant for haemolysis as well as the number of sugar moieties. In addition it was found that haemolysis by saikosaponins is inhibited by the addition of adenine and inosine to the incubation medium.

Key Word Index

Bupleurum falcatum L - Saikosaponin - Haemolysis