Hormonal Profile of Coronaridine Hydrochloride – an Antifertility Agent of Plant Origin¹

Abstract

The hormonal properties of coronaridine hydrochloride were investigated. A single oral administration of the compound (30 mg/kg) prevented pregnancy in rats when given on days 1, 2, 3 or 4 post–coitum; the effect on days 5, 6, 7 or 8 of pregnancy was, however, partial. The substance showed estrogenic activity but was devoid of antiestrogenic, androgenic, antiandrogenic, progestational, antiprogestational and uterine stimulant activities; however, there was a partial inhibition of oxytocin–induced uterine response. Coronaridine appears to exert its antifertility action due to its frank estrogenicity.

Key Word Index

Coronaridine hydrochloride - Antifertility Action - Oestrogenic Activity