Antimicrobial Effect of the Alkaloids from Strychnos afzelii Gilg.

R. Verpoorte; E. W. Kode; H. van Doorne; A. Baerheim Svendsen

doi:10.1055/s-0028-1097382

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Planta Med 1978; 33(3): 237-242
DOI: 10.1055/s-0028-1097382

Antimicrobial Effect of the Alkaloids from Strychnos afzelii Gilg.

R. Verpoorte, E. W. Kode, H. van Doorne, A. Baerheim Svendsen

Department of Pharmacognosy, University of Leiden, The Netherlands.

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Publication Date:
13 January 2009 (online)

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Abstract

The use of Strychnos afzelii Gilg (Loganiaceae) stem as chewing stick have been reported by several authors [1]. Extracts of the stem bark were found to exhibit antimicrobial activity, among others against Streptococcus species connected with caries. In the extracts the alkaloids bisnor–dihydrotoxiferine (I), bisnor–C–alkaloid H (II), caracurine V (IV) and Wieland–Gum–lich aldehyde (V) were identified. The tertiary dimeric indole alkaloids I, II and IV were found to be responsible for the antimicrobial effect.

Key Word Index

Strychnos afzelii - Alkaloids - Antimicrobial Effects