Abstract
A literature survey on the structures and specificities of enzyme inhibitors isolated
from microorganisms is presented, with special emphasis on protease inhibitors and
inhibitors of adrenaline metabolism.
In addition a new group of glycoside hydrolase inhibitors isolated from actinomycetes
is discussed in detail, with special reference to detection, production, pharmacological
effects and structure of the inhibitors. An integral part in the chain of α–1,4–linked
D–glucopyranose units is a core structure consisting of an unsaturated cyclitol unit
bound to 4,6–dideoxy–4–amino–D–glucopyranose.
The low molecular weight homologues are potent sucrase inhibitors whereas the inhibitors
of higher molecular weight are specific for α–amylase.
Key Word Index
Enzyme Inhibitors - Protease Inhibitors - Amylase Inhibitors - Sucrase Inhibitors
- Microorganisms - Actinomycetes
