Semin Reprod Med 2008; 26(6): 494-499
DOI: 10.1055/s-0028-1096129
© Thieme Medical Publishers

Regulation of Uterine Matrix Metalloproteinase-9 and the Role of MicroRNAs

Warren B. Nothnick1
  • 1Associate Professor, Departments of Obstetrics & Gynecology and Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas
Further Information

Publication History

Publication Date:
24 October 2008 (online)

ABSTRACT

Controlled expression of matrix metalloproteinase-9 (MMP9) is vital for normal uterine physiology, whereas abnormal expression of MMP9 is associated with uterine disease. Despite the importance of MMP9 within the uterus, its regulation is poorly understood. In this review, the complex regulation of MMP9 within the uterus is highlighted, and the potential novel role of microRNAs in the regulation of this protease is discussed. Emphasis is placed on the necessity to enhance our understanding of the regulation of MMP9 expression, which may lead to the establishment of novel approaches to counteract misexpression of this protease and the diseases associated with it.

REFERENCES

Warren B Nothnick, Ph.D. 

Associate Professor, Departments of Obstetrics & Gynecology and Molecular & Integrative Physiology, University of Kansas Medical Center

Mail stop 2028, 3901 Rainbow Boulevard, Kansas City, KS 66160

Email: [email protected]