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Horm Metab Res 1970; 2(1): 6-8
DOI: 10.1055/s-0028-1095118
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Short-Term Tolbutamide Treatment on Insulin Dynamics in Newly Diagnosed Obese and Non-Obese Adult Diabetics

B. L. Wajchenberg , K.  Nakasone , K.  Pasternak
  • Diabetes and Adrenal Unit, Hospital das Clinicas and Radiobiology Section, Instituto de Energia Atomica, Sao Paulo, Brazil
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Blood glucose and plasma insulin responses to oral glucose and I.V. tolbutamide were measured before and after 2-month oral treatment with tolbutamide in 5 patients with maturity-onset diabetes. The improvement in glucose tolerance was not associated with an increase in plasma insulin, but with a decrease in its output, after I.V. tolbutamide, in the non-obese and no change in the obese, probably related to the maintenance of obesity and the insulin antagonism associated with it.

Key words

Oral GTT - Tolbutamide Test - Insulin Response - Obesity - Maturity Onset Diabetes