E. coli L-asparaginase 250 and 500 U/kg given in a single IV dose did not produce
hyperglycemia or glycosuria in rabbits. Prednisolone 1 mg/kg/day administered for
14 days was also nondiabetogenic. A combination of L-asparaginase 500 U/kg with prednisolone
was diabetogenic in all the animals. The results suggest that the two drugs act synergistically
in producing the diabetogenic effect The clinical significance of these findings was
discussed.
L-Asparaginase - Prednisolone - Synergism - Diabetogenic Effect - Enzyme
