Metabolic clearance rates (MCR) and production rates (PR) of human thyroid-stimulating
hormone (TSH) were determined in seven subjects with normal thyroid function, six
thyrotoxic patients and three others suffering from long-standing myxedema. Three
patients with severe renal insufficiency were also investigated. Using the h-TSH Research
Standard-A as reference, the PR in normal subjects averaged 419 mU of TSH per day.
The results obtained in cases of abnormal thyroid function stress the interest of
this type of investigation in the evaluation of the TSH production rate.
Metabolic Clearance Rate of TSH - Production Rate of TSH - Thyrotoxicosis - Myxedema
