Abstract
Intravenous tolbutamide evoked an exaggerated hyperinsulinemia in persons with mild
glucose intolerance, i.e. in those with equivocal Glucose Tolerance Sums or so-called
chemical or latent diabetes. The tolbutamide-induced hyperinsulinemia was greater
in those who were older and in those who were overweight. Such hyperinsulinemic responses
in association with this limited degree of glucose intolerance were also present in
the younger and older members of the non-overweight group.
Such individuals with mild glucose intolerance and an exaggerated tolbutamide-induced
hyperinsulinemia also developed greater increments in serum insulin following the
ingestion of glucose.
Key words
Glucose Intolerance - Tolbutamide - Hyperinsulinemia
1 Aided by grants from the Addison H. Gibson Foundation, John and Rosalind Redfern,
the Pittsburgh Foundation (Charles A. Locke Educational and Charitable Trust), and
the Commonwealth of Pennsylvania
