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Horm Metab Res 1971; 3(3): 180-183
DOI: 10.1055/s-0028-1094152
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© Georg Thieme Verlag KG Stuttgart · New York

Comparison of Secretin Response to Oral Intraduodenal or Intravenous Glucose Administration[*]

D. J. Chisholm [**] , E. W. Kraegen , J. D. Young , L.  Lazarus
  • Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Previous studies of the pancreatic exocrine response to intraduodenal glucose administration have not demonstrated the release of secretin; consequently, the importance of secretin in the enteric insulin release mechanism has been questioned.

In this study, serum levels of secretin were estimated by radioimmunoassay in three normal subjects after oral, intravenous or intraduodenal administration of glucose (1 gm per Kg). No secretin response was recorded during the intravenous study but similar peak levels (12 to 18 ng per ml) were observed with the oral and intraduodenal routes of administration. The initial response was rapid in both instances, but the effect was more prolonged after intraduodenal administration. As secretin is known to potentiate the glycaemic release of insulin, it is postulated that this hormone is a major factor in the augmented insulin response observed during both oral and intraduodenal studies.

Key words

Secretin Release - Insulin Release - Glucose Administration - Radioimmunoassay

1 * Supported by a grant from the National Health and Medical Research Council of Australia.

1 * Supported by a grant from the National Health and Medical Research Council of Australia.

2 ** Present address: Royal Victoria Hospital, Montreal, Canada.