The Influence of Lactate on Muscle Metabolism

P. Dieterle; P. Banholzer; R. Dieterle; J. Henner; K. Schwarz

doi:10.1055/s-0028-1094139

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Horm Metab Res 1971; 3(5): 340-344
DOI: 10.1055/s-0028-1094139

Originals

The Influence of Lactate on Muscle Metabolism[*]

Lactate as a Possible Regulating Factor for the Increased Energy Supply During Muscular WorkP. Dieterle , P. Banholzer , R. Dieterle , J. Henner , K. Schwarz

II . Medical Clinic, Department of Endocrinology, University of Munich, Germany

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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

Lactic acid stimulates the release of glycerol significantly in vitro in the resting muscle. Although glycerol release is enhanced by lactate there are no FFA released into the medium. In contrast high concentration of lactate in the medium stimulates the uptake of FFA into the muscle significantly. In the presence of glucose lactate promotes the resynthesis of glycogen. The influences of lactic acid upon the muscle metabolism are discussed. It may be speculated that the elevated concentration of lactate increases the supply of substrates in muscle during exercise.

Key words

Muscle Metabolism - Exercise - Self-regulating Muscle Factor - Lactate - Glycerol Release - Free Fatty Acid Uptake

1 Supported by grants from the Deutsche Forschungsgemeinschaft, Bad Godesberg