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Horm Metab Res 1972; 4(1): 22-25
DOI: 10.1055/s-0028-1094110
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© Georg Thieme Verlag KG Stuttgart · New York

Lipogenic Activity of a Potent Lipolytic Hormone: Sheep β Lipotropin (β-LPH) - II. Further Effects of Sheep β-LPH on Specifically Labeled Glucose and the Localization of Lipogenic Active Center of the Molecule

P.  Bielmann , M.  Chrétien , A.  Gattereau
  • Nutrition and Pituitary Hormones Laboratories, Clinical Research Institute, Montreal, P.Q., Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

A study of β-LPH on specifically labeled glucose metabolism by epididymal fat pads in vitro showed that β-LPH enhanced the conversion of both 1-14C and 6-14C glucose to CO2 and fatty acids. The adipose tissue oxidized glucose-1-I4C to CO2 to a greater extent than glucose-6-14C and presence of β-LPH did not change this usual pattern. Studies with βh- MSH and with five fragments of the β-LPH molecule obtained by cleavage with cyanogen bromide show that the center for lipogenic activity involves the sequence 48-65, but additional amino acids at either end of this core are necessary before noticeable lipogenic activity appears. A similar sequence is known to be required for lipolytic activity.

Key words

β-Lipotropic Hormone - β-Melanocyte Stimulating Hormone - Lipogenesis - Lipolysis - Glucose

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