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Horm Metab Res 1972; 4(3): 176-178
DOI: 10.1055/s-0028-1094043
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© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Lipid Synthesis by Epinephrine in Isolated Rat Liver Cells[*]

R. I. Misbin , D. M. Capuzzi , S.  Margolis
  • Clayton Laboratories, Department of Medicine and Department of Physiological Chemistry The Johns Hopkins University, Baltimore, Maryland, USA
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Epinephrine produced a uniform inhibition of the incorporation of 14C-acetate into all classes of cellular lipids in isolated rat liver cells. The reduced label in cellular lipids did not result from an increased release of labeled lipids into the incubation medium or from an enhanced degradation of labeled lipids. Cyclic 3',5' AMP affected acetate incorporation in a manner similar to epinephrine. These observations suggest that epinephrine inhibits an early step in the biosynthetic pathway of lipids, and that the action of epinephrine may be mediated by stimulation of adenyl cyclase activity.

Key words

Lipid Synthesis - Isolated Rat Liver Cells - Epinephrine - Adrenalin - Cyclic 3',5' AMP - Adenyl Cyclase

1 This work was supported by grants from the United States Public Health Service (HE09506 and AM5136)

1 This work was supported by grants from the United States Public Health Service (HE09506 and AM5136)

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