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Horm Metab Res 1973; 5(3): 213-215
DOI: 10.1055/s-0028-1093955
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Oxytocin and Epinephrine on the Adenylate Cyclase Activity of Myometrium from Pregnant Rhesus Monkeys

Clarissa H. Beatty , R. M. Bocek , M. K. Young
  • Division of Reproduction Biology, Oregon Regional Primate Research Center, Beaverton, Oregon, Department of Biochemistry, University of Oregon Medical School, Portland, Oregon, USA
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

The effects of oxytocin and epinephrine on the adenyl cyclase activity of myometrial slices from pregnant rhesus monkeys (Macaca mulatta) near term were measured by the conversion of ATP-14C to cyclic AMP-14C. ATP was prelabeled by incubation with adenine-8-14C. In the presence of caffeine, oxytocin at 2.5 and 5.0 × 10-8M concentrations stimulated adenyl cyclase activity to the same extent. Epinephrine, 1 × 10-7M, also caused an increase in the adenyl cyclase activity in the presence of caffeine.

Key words

Pregnant Rhesus - Myometrium - Oxytocin - Epinephrine - Adenylate Cyclase