Horm Metab Res 1973; 5(4): 275-279
DOI: 10.1055/s-0028-1093946

© Georg Thieme Verlag KG Stuttgart · New York

Effect of Methandienone on Free Fatty Acid and Triglyceride Turnover in Normal Females

A. H. Kissebah [*] , P.  Harrigan , P. W. Adams , V.  Wynn
  • The Alexander Simpson Laboratory for Metabolic Research, St. Mary's Hospital Medical School, London, W. 2, England
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Publication History

Publication Date:
07 January 2009 (online)


The effect of methandienone therapy on the concentration, turnover and removal rates of serum triglyceride have been studied in premenopausal women by endogenous labelling of triglyceride during a 14C palmitate infusion. Fifteen women served as controls, of whom five were also studied following a minimum of four weeks therapy.

Treatment with methandienone was associated with a marked increase in triglyceride turnover. At the same time, there was accelerated triglyceride clearance associated with a significant increase in plasma post-heparin lipolytic activity. The resulting serum triglyceride concentration during therapy remained within the normal range although there was a significant increase following the introduction of methandienone. The observed increase in the triglyceride turnover was not associated with a concordant change in either free fatty acid concentration or free fatty acid turnover rate. Triglyceride turnover and plasma post-heparin lipolytic activity were significantly correlated with the peak plasma insulin responses during a standard oral glucose tolerance test.

1 Present address: Royal Postgraduate Medical School, Hammersmith Hospital, London, W. 12, England.