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Horm Metab Res 1974; 6(1): 21-25
DOI: 10.1055/s-0028-1093897
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Pancreozymin in Rabbits

C.  Lucke , B.  Höffken , H. J. Mitzkat , I.  Trautschold
  • Division of Clinical Endocrinology and Division of Diabetology, Department of Medicine, Department of Biochemistry, Medizinische Hochschule Hannover, Hannover, Germany
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Publication Date:
07 January 2009 (online)

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Abstract

Plasma insulin levels were measured in rabbits in response to pancreozymin and secretin. Suppression of intestinal hormone induced insulin secretion was attempted by pre-treatment with mannoheptulose and with 2-deoxy-D-glucose. The response to pancreozymin was not significantly altered by 2-deoxy-D-glucose, but was suppressed to a mean of 38.5% of control values by mannoheptulose. - Secretin did not induce insulin secretion in this model.

The data suggest that blockade of glycolysis interferes with pancreozymin-induced insulin release depending on the site of blockade.

Key words

Gastrointestinal Hormones - Pancreozymin - Secretin - Insulin - Mannoheptulose - 2-Deoxy-D-Glucose