Abstract
The stop flow patterns of free and glucuronide conjugated Cortisol were studied in
five anesthetized dogs. The results indicate that free Cortisol was reabsorbed primarily
along the distal tubules. ACTH had no effect on the reabsorption of free Cortisol
by the distal tubules, but it did increase free Cortisol reabsorption by the proximal
tubules. The stop flow patterns for Cortisol glucuronide demonstrate that this conjugated
steroid was secreted along the entire length of the renal tubules and ACTH had no
effect on its secretion.
Key words
Cortisol Reabsorption Site - ACTH on Reabsorption Site - Stop Flow Cortisol
1 These studies were supported in part by internal grants of the University of Illinois
and the Office of Naval Research Contract NR 101-580.
2 Present address: Department of Physiology, Faculty of Medicine, Chiang Mai University,
Chiang Mai, Thailand.
