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Horm Metab Res 1974; 6(2): 154-157
DOI: 10.1055/s-0028-1093882
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© Georg Thieme Verlag KG Stuttgart · New York

Renal Handling of Cortisol in Dogs - II. Effect of ACTH on Stop Flow Pattern[*]

U.  Boonayathap [**] , S. F. Marotta
  • Department of Physiology, University of Illinois, School of Basic Medical Sciences, Chicago, Illinois, U.S.A.
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

The stop flow patterns of free and glucuronide conjugated Cortisol were studied in five anesthetized dogs. The results indicate that free Cortisol was reabsorbed primarily along the distal tubules. ACTH had no effect on the reabsorption of free Cortisol by the distal tubules, but it did increase free Cortisol reabsorption by the proximal tubules. The stop flow patterns for Cortisol glucuronide demonstrate that this conjugated steroid was secreted along the entire length of the renal tubules and ACTH had no effect on its secretion.

Key words

Cortisol Reabsorption Site - ACTH on Reabsorption Site - Stop Flow Cortisol

1 These studies were supported in part by internal grants of the University of Illinois and the Office of Naval Research Contract NR 101-580.

1 These studies were supported in part by internal grants of the University of Illinois and the Office of Naval Research Contract NR 101-580.

2 Present address: Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.