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Horm Metab Res 1974; 6(4): 306-308
DOI: 10.1055/s-0028-1093835
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© Georg Thieme Verlag KG Stuttgart · New York

Increase in the Amount of Iodide Released from the Thyroid after Perchlorate or Carbimazole Administration

F.  Berthezene , Bernadette  Chavrier , R.  Mornex
  • Service d' Endocrinotogie et des Maladies de la Nutrition, Hôpital de l'Antiquaille, Lyon Cedex 1, France
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Publikationsdatum:
08. Januar 2009 (online)

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Abstract

Administration of 40 mg carbimazole or 500 mg perchlorate to twelve normal subjects gave an increase in plasma inorganic iodine and urinary iodide excretion. The increase in the amount of extracellular fluid and urinary iodide was almost 4 times the absolute iodide uptake by the thyroid. It appears that perchlorate and carbimazole act not only in blocking thyroid iodide uptake but also in accelerating thyroidal iodide release. So both of these drugs can be used for the plasma inorganic iodine increase test which appreciates thyrotropic function.

Key words

Iodide - Thyroid - Perchlorate - Carbimazole