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Horm Metab Res 1975; 7(2): 173-175
DOI: 10.1055/s-0028-1093772
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Thyroid Function in Osteogenesis Imperfecta

L. A. Distiller , J.  Sagel , S.  Jacobson
  • Endocrine Unit, Department of Medicine, University of the Witwatersrand Medical School, and Department of Pediatrics, Baragwanath Hospital, Johannesburg, South Africa
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

Osteogenesis imperfecta is associated with raised total serum thyroxine levels and a hypermetabolic state. In Order to determine the role of thyroid dysfunction, 6 children with this disease were studied. All subjects had a raised serum T4 in the presence of a low T3 resin and normal free thyroxine index. The TSH response to TRH was normal. The serum protein estimation revealed an elevated globulin fraction. It is suggested that the raised T4 in osteogenesis imperfecta is due to an excess globulin component, and thyroid function in this disease is not disturbed.

Key words

Osteogenesis Imperfecta - Thyroid Function - TRH-TSH - Serum Proteins