Inhibitory Effect of Amitriptyline on Exercise-Induced Lipid Mobilization in Rats

G. Federspil; C. De Palo; M. Zaccaria; N. Sicolo

doi:10.1055/s-0028-1093769

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000025.xml

Share / Bookmark

Facebook Linkedin Weibo

Download PDF

Horm Metab Res 1975; 7(2): 158-161
DOI: 10.1055/s-0028-1093769

Originals

Inhibitory Effect of Amitriptyline on Exercise-Induced Lipid Mobilization in Rats[*]

G. Federspil , C. De Palo , M. Zaccaria , N. Sicolo

Institute of Semeiotica Medica, University of Padua, Padua, Italy

Further Information

Publication History

Publication Date:
23 December 2008 (online)

Also available at

Abstract
PDF (144 kb)
References

PDF Download Permissions and Reprints

Abstract

The effects of administration of Amitriptyline on lipolysis induced by prolonged muscular exercise in rats were investigated.

In rats at rest Amitriptyline produced a moderate hyperglycemia and a slight rise of plasma FFA.

In the untreated rats submitted to prolonged muscular exercise (forced swim), physical activity caused an evident increase in plasma FFA and glycerol. In the animals treated with Amitriptyline, however, the plasma FFA and glycerol increase was blocked.

This blockade of lipid mobilization caused by Amitriptyline is compatible with the idea that fatty acids increase induced by muscular work is due to stimulation of the lipolytic system activated by cyclic AMP. The hypothesis is proposed that ACTH may play an important role in the exercise-induced fatty acids mobilization in rats.

Key words

Amitryptiline - Cyclic AMP - Free Fatty Acids - Glucose - Glycerol - Lipolysis - Muscular Exercise

1 Supported in part from C.N.R., Research grant n. 72.00636.04